Evidence map›Paper›PMID 35332242›Full record

ArticleScientific reports2022

Multimodal microwheel swarms for targeting in three-dimensional networks.

C J Zimmermann, P S Herson, K B Neeves, D W M Marr

Abstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Aligned colloidal clusters in an alternating rotating magnetic field elucidated by magnetic relaxation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Coupling magnetic torque and force for colloidal microbot assembly and manipulation.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  7. Article
  8. Review
  9. Paddlebots: Translation of Rotating Colloidal Assemblies near an Air/Water Interface.Langmuir : the ACS journal of surfaces and colloids · 2023
    Article
  10. Article
  11. Delivery and actuation of aerosolized microbots.Nano select : open access · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

C J ZimmermannDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA.
P S HersonDepartment of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
K B NeevesDepartment of Bioengineering, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
D W M MarrDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, USA. dmarr@mines.edu.

Funding

Magnetically propelled microwheels for rapid thrombolysis in small arteriesR01NS102465 · NINDS · COLORADO SCHOOL OF MINES · PI MARR, DAVID WM, NEEVES, KEITH B · 2018 to 2022
$2.6M
Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilmsR21AI138214 · NIAID · COLORADO SCHOOL OF MINES · PI MARR, DAVID WM, NEEVES, KEITH B · 2019 to 2020
$419k
NIAID NIH HHS R21 AI138214NINDS NIH HHS R01 NS102465
6 · The paper itself

Abstract

Microscale bots intended for targeted drug delivery must move through three-dimensional (3D) environments that include bifurcations, inclined surfaces, and curvature. In previous studies, we have shown that magnetically actuated colloidal microwheels (µwheels) reversibly assembled from superparamagnetic beads can translate rapidly and be readily directed. Here we show that, at high concentrations, µwheels assemble into swarms that, depending on applied magnetic field actuation patterns, can be designed to transport cargo, climb steep inclines, spread over large areas, or provide mechanical action. We test the ability of these multimodal swarms to navigate through complex, inclined microenvironments by characterizing the translation and dispersion of individual µwheels and swarms of µwheels on steeply inclined and flat surfaces. Swarms are then studied within branching 3D vascular models with multiple turns where good targeting efficiencies are achieved over centimeter length scales. With this approach, we present a readily reconfigurable swarm platform capable of navigating through 3D microenvironments.

Indexed as

Drug Delivery SystemsMagnetic Fields

Identifiers

PMID35332242
PMCPMC8948265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.