ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022
Phase 1 Evaluation of
Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase I
In one paragraph
Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06591429 (Investigation of Smoldering Inflammation in Multiple Sclerosis), which is not on this map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Smoldering Inflammation in Multiple Sclerosis
Who cites it
17 citing papers in PubMed, 13 citations in OpenAlex.
- [11C]CS1P1 PET links T-cell-associated immune activation with endothelial and astrocytic responses.Research square · 2026Article
- Kinetic Modeling of a Novel Putative Sphingosine-1-Phosphate Receptor 1 (S1PR1) Radiotracer [Journal of neurochemistry · 2026Article
- Evaluation of [AJNR. American journal of neuroradiology · 2026Article
- Automated production of radiotracer [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025Article
- PET Study of S1PR1 Expression in Rodent Model of Myocardial Infarction.Molecular imaging and biology · 2025Article
- PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [Molecular imaging and biology · 2025Article
- PET imaging of neuroinflammation: any credible alternatives to TSPO yet?Molecular psychiatry · 2025Review
- Design, synthesis, and biological evaluation of multiple F-18 S1PR1 radiotracers in rodent and nonhuman primate.Organic & biomolecular chemistry · 2024Article
- PET Imaging of Sphingosine-1-Phosphate Receptor 1 with [18F]TZ4877 in Nonhuman Primates.Research square · 2024Article
- Metabolite Study and Structural Authentication for the First-in-Human Use Sphingosine-1-phosphate Receptor 1 Radiotracer.ACS chemical neuroscience · 2024Article
- Diffusion basis spectrum imaging and diffusion tensor imaging predict persistent black hole formation in multiple sclerosis.Multiple sclerosis and related disorders · 2024Article
- Quantitative Analysis of S1PR1 Expression in the Postmortem Multiple Sclerosis Central Nervous System.ACS chemical neuroscience · 2023Article
- Discovery of a Promising Fluorine-18 Positron Emission Tomography Radiotracer for Imaging Sphingosine-1-Phosphate Receptor 1 in the Brain.Journal of medicinal chemistry · 2023Article
- Positron Emission Tomography of Neuroimmune Responses in Humans: Insights and Intricacies.Seminars in nuclear medicine · 2023Review
- Recent Developments in Carbon-11 Chemistry and Applications for First-In-Human PET Studies.Molecules (Basel, Switzerland) · 2023Review
- Imaging and targeting S1PR1 in HER2+ tumors.Nuclear medicine and biologyArticle
- Imaging Sphingosine-1-Phosphate Receptor: A Promising Strategy to Neuroinflammation of Epilepsy.Molecular imagingReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 2 institutions in 1 country.
Matthew R BrierDepartment of Neurology, Washington University, St. Louis, Missouri.
Mahdjoub HamdiMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Jayashree RajamanikamMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Haiyang ZhaoMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Syahir MansorMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Lynne A JonesMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Farzaneh RahmaniMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Saurabh JindalMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Deborah KoudelisMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Joel S PerlmutterDepartment of Neurology, Washington University, St. Louis, Missouri.
Dean F WongDepartment of Neurology, Washington University, St. Louis, Missouri.
Michael NickelsMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Joseph E IppolitoMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Robert J GroplerMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Thomas H SchindlerMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Richard LaforestMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Zhude TuMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri; benzingert@wustl.edu zhudetu@wustl.edu.
Tammie L S BenzingerMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri; benzingert@wustl.edu zhudetu@wustl.edu.
Mallinckrodt (United States) · USWashington University in St. Louis · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MTraining/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7MPET SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 (S1PR1) RADIOTRACERS FOR MULTIPLE SCLEROSISR01NS103988 · NINDS · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger, Zhude Tu · 2017 to 2026
$5.3MPET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTERR01NS075527 · NINDS · WASHINGTON UNIVERSITY · PI TU, ZHUDE · 2011 to 2021
$4.9MQuantification of Neuroinflammation inAlzheimer's Disease Using Diffusion BasisSpectrum ImagingR01AG054567 · NIA · WASHINGTON UNIVERSITY · PI BENZINGER, TAMMIE LEE SMITH, WANG, YONG · 2017 to 2021
$3.6MNeuroinflammatory Biomarkers for Nigrostriatal InjuryR01NS107281 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES · 2019 to 2023
$3.3MNeuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1MTraining OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4MWASHINGTON UNIVERSITY NEUROSURGERY RESIDENT RESEARCH EDUCATION PROGRAMR25NS090978 · NINDS · WASHINGTON UNIVERSITY · PI ZIPFEL, GREGORY J · 2015 to 2023
$2.1MPURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0MNCATS NIH HHS UL1 TR002345NIA NIH HHS P01 AG003991NIA NIH HHS R01 AG054567NIA NIH HHS U19 AG032438NIBIB NIH HHS P41 EB025815NIBIB NIH HHS T32 EB021955NIH HHS S10 OD025214NINDS NIH HHS R01 NS075527NINDS NIH HHS R01 NS103957NINDS NIH HHS R01 NS103988NINDS NIH HHS R01 NS107281NINDS NIH HHS R01 NS134586NINDS NIH HHS R25 NS090978
Abstract
This study evaluated the safety, dosimetry, and characteristics of 3-((2-fluoro-4-(5-(2'-methyl-2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1,2,4-oxadiazol-3-yl)benzyl)(methyl-
Indexed as
Multiple SclerosisPositron-Emission TomographyAdultAnimalsFemaleHumansMaleRadiometryRadiopharmaceuticalsTissue DistributionRadiopharmaceuticalscerebral inflammationPETradiation dosimetrysphingosine-1-phosphatespingosine-1-phosphate receptors
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT06591429ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.