Evidence map›Paper›PMID 35332085›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons.

Carol M Upchurch, Crescent L Combe, Christopher J Knowlton, Valery G Rousseau, Sonia Gasparini, Carmen C Canavier

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. CaInternational journal of molecular sciences · 2026
    Article
  3. Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Mild focal cooling selectively impacts computations in dendritic trees.bioRxiv : the preprint server for biology · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carol M UpchurchDepartment of Cell Biology & Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.
Crescent L CombeNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.ORCID https://orcid.org/0000-0003-1181-6569
Christopher J KnowltonDepartment of Cell Biology & Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.
Valery G RousseauDepartment of Cell Biology & Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.
Sonia GaspariniDepartment of Cell Biology & Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112 sgaspa1@lsuhsc.edu.ORCID https://orcid.org/0000-0001-5847-9315
Carmen C CanavierDepartment of Cell Biology & Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112.ORCID https://orcid.org/0000-0003-4368-6906
Louisiana State University Health Sciences Center New Orleans · US

Funding

CRCNS: Cholinergic contribution to hippocampal information processingR01MH115832 · NIMH · LSU HEALTH SCIENCES CENTER · PI CANAVIER, CARMEN CASTRO, GASPARINI, SONIA · 2017 to 2021
$1.8M
NIMH NIH HHS R01 MH115832
6 · The paper itself

Abstract

Many hippocampal CA1 pyramidal cells function as place cells, increasing their firing rate when a specific place field is traversed. The dependence of CA1 place cell firing on position within the place field is asymmetric. We investigated the source of this asymmetry by injecting triangular depolarizing current ramps to approximate the spatially tuned, temporally diffuse depolarizing synaptic input received by these neurons while traversing a place field. Ramps were applied to CA1 pyramidal neurons from male rats

Indexed as

DendritesPyramidal CellsAction PotentialsAnimalsHippocampusIn Vitro TechniquesMaleRatsSodium ChannelsSodium ChannelsdendritehippocampusK channelmodulationNa channelplace cells

Identifiers

PMID35332085
PMCPMC9087813
OpenAlexW4220833608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.