ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Columnar Localization and Laminar Origin of Cortical Surface Electrical Potentials.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Association between motor cortex grey matter loss and inability to control an ECoG-based implanted Brain-Computer Interface in ALS.medRxiv : the preprint server for health sciences · 2026Article
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- Resolving non-identifiability mitigates systematic errors in simultaneous models of neural tuning and functional coupling.Journal of computational neuroscience · 2026Article
- Distinct laminar origins of sensory-evoked high-gamma and low-frequency ECoG signals revealed by optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.Nature communications · 2026Article
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Neurons in auditory cortex integrate information within a constrained and context-invariant temporal window.Current biology : CB · 2025Article
- Distinct laminar origins of high-gamma and low-frequency ECoG signals revealed by optogenetics.bioRxiv : the preprint server for biology · 2025Article
- Neurons in auditory cortex integrate information within constrained temporal windows that are invariant to the stimulus context and information rate.bioRxiv : the preprint server for biology · 2025Article
- A large-scale optogenetic neurophysiology platform for improving accessibility in non-human primate behavioral experiments.bioRxiv : the preprint server for biology · 2025Article
- Layers of the monkey visual cortex are selectively modulated during electrical stimulation.PLoS biology · 2025Article
- Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents.Journal of visualized experiments : JoVE · 2025Article
- BlueRecording: A pipeline for the efficient calculation of extracellular recordings in large-scale neural circuit models.PLoS computational biology · 2025Article
- On the validity of electric brain signal predictions based on population firing rates.PLoS computational biology · 2025Article
- Dynamic changes in large-scale functional connectivity prior to stimulation determine performance in a multisensory task.Frontiers in systems neuroscience · 2025Article
- The geometry of correlated variability leads to highly suboptimal discriminative sensory coding.Journal of neurophysiology · 2025Article
- Bayesian inference of structured latent spaces from neural population activity with the orthogonal stochastic linear mixing model.PLoS computational biology · 2024Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Electrocorticography (ECoG) methodologically bridges basic neuroscience and understanding of human brains in health and disease. However, the localization of ECoG signals across the surface of the brain and the spatial distribution of their generating neuronal sources are poorly understood. To address this gap, we recorded from rat auditory cortex using customized μECoG, and simulated cortical surface electrical potentials with a full-scale, biophysically detailed cortical column model. Experimentally, μECoG-derived auditory representations were tonotopically organized and signals were anisotropically localized to less than or equal to ±200 μm, that is, a single cortical column. Biophysical simulations reproduce experimental findings and indicate that neurons in cortical layers V and VI contribute ∼85% of evoked high-gamma signal recorded at the surface. Cell number and synchrony were the primary biophysical properties determining laminar contributions to evoked μECoG signals, whereas distance was only a minimal factor. Thus, evoked μECoG signals primarily originate from neurons in the infragranular layers of a single cortical column.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.