Evidence map›Paper›PMID 35332081›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Arrestin Facilitates Rhodopsin Dephosphorylation

Chia-Ling Hsieh, Yun Yao, Vsevolod V Gurevich, Jeannie Chen

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Structure and self-association of Arrestin-1.Journal of structural biology · 2025
    Review
  2. Posttranslational modifications of proteins in diseased retina.Frontiers in cellular neuroscience · 2023
    Review
  3. Article
  4. Solo vs. Chorus: Monomers and Oligomers of Arrestin Proteins.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chia-Ling HsiehZiliha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California 90089.
Yun YaoZiliha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California 90089.
Vsevolod V GurevichDepartment of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Jeannie ChenZiliha Neurogenetic Institute, Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, California 90089 Jeannie@usc.edu.ORCID https://orcid.org/0000-0002-7904-9629
University of Southern California · USVanderbilt University · US

Funding

STRUCTURE/FUNCTION STUDIES OF VISUAL ARRESTINR01EY011500 · NEI · VANDERBILT UNIVERSITY · PI T M Iverson · 1997 to 2026
$12.3M
Phototransduction in health and diseaseR01EY012155 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeannie Chen · 1998 to 2026
$11.8M
Ophthalmic Therapeutics Engineering CoreP30EY029220 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Mahnaz Shahidi · 2018 to 2026
$6.5M
NEI NIH HHS P30 EY029220NEI NIH HHS R01 EY011500NEI NIH HHS R01 EY012155
6 · The paper itself

Abstract

Deactivation of G-protein-coupled receptors (GPCRs) involves multiple phosphorylations followed by arrestin binding, which uncouples the GPCR from G-protein activation. Some GPCRs, such as rhodopsin, are reused many times. Arrestin dissociation and GPCR dephosphorylation are key steps in the recycling process.

Indexed as

ArrestinRhodopsinAnimalsFemaleGTP-Binding ProteinsMaleMicePhosphorylationRetinal Rod Photoreceptor CellsArrestinGTP-Binding ProteinsRhodopsinarrestindephosphorylationGPCRPP2Arhodopsin

Identifiers

PMID35332081
PMCPMC9053844
OpenAlexW4220799809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.