Trial reportHeart (British Cardiac Society)2023
Sex difference in atrial fibrillation recurrence after catheter ablation and antiarrhythmic drugs.
Trial report in Heart (British Cardiac Society), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02138695 (The Evaluation for Prognostic Factors After Catheter Ablation of Atrial Fibrillation), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Evaluation for Prognostic Factors After Catheter Ablation of Atrial Fibrillation: Cohort Study
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Sex-based disparities in postoperative outcomes after catheter ablation for atrial fibrillation: a systematic review and meta-analysis of propensity-matched studies.BMC cardiovascular disorders · 2026Pooled it
- Inequitable Access to Catheter Ablation for Atrial Fibrillation and Adverse Outcomes in a Publicly Funded Healthcare System.CJC open · 2026Article
- Construction of a regression model and post-procedure care strategy for predicting atrial fibrillation recurrence risk after radiofrequency ablation using combined P-wave electrocardiographic markers and serum.Frontiers in cardiovascular medicine · 2026Article
- Non-alcoholic fatty liver disease as a predictor of atrial fibrillation recurrence following ablation: a retrospective study.Cardiovascular diagnosis and therapy · 2025Article
- Sex-Related Differences in Non-Pulmonary Vein Triggers During Initial Atrial Fibrillation Ablation.JAMA network open · 2025Article
- Digital twin for sex-specific identification of class III antiarrhythmic drugs based on in vitro measurements, computer models, and machine learning tools.PLoS computational biology · 2025Article
- Artificial intelligence-estimated electrocardiographic sex as a recurrence predictor after atrial fibrillation catheter ablation.European heart journal. Digital health · 2025Article
- Atrial Fibrillation and Heart Failure: Synergistic Effect on Functional Class and Quality of Life.Clinical cardiology · 2025Article
- Risk factors for the recurrence of atrial fibrillation after catheter ablation: a meta-analysis.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Review
- Evolution in electrophysiology 100 years after Einthoven: translational and computational innovations in rhythm control of atrial fibrillation.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Catheter Ablation in Atrial Fibrillation: Recent Advances.Journal of clinical medicine · 2024Review
- Enhanced CaJACC. Clinical electrophysiology · 2024Article
- Ablation Compared to Pharmacological Treatment for the Reduction of Atrial Fibrillation Recurrence: A Meta-Analysis.Cureus · 2024Review
- Risk and Protective Factors of Recurrence after Catheter Ablation for Atrial Fibrillation.Reviews in cardiovascular medicine · 2024Review
- Cardiac Radiofrequency Ablation Exacerbates Myocardial Injury through Pro-Inflammatory Response and Pro-Oxidative Stress in Elderly Patients with Persistent Atrial Fibrillation.Current vascular pharmacology · 2024Article
- Selected Advances in the Anti-arrhythmic Management of Atrial Fibrillation: 2023.The Journal of innovations in cardiac rhythm management · 2024Article
- Do extra-pulmonary triggers or autonomic neural activity affect rhythm control by anti-arrhythmic drugs in patients with post-ablation atrial fibrillation recurrence?Frontiers in cardiovascular medicine · 2024Article
- Predictors of Low Voltage Zone and Sex Differences in Low Voltage Zone Distribution in Patients with Atrial Fibrillation.Reviews in cardiovascular medicine · 2023Article
- Sex-related differences in presentation, treatment, and outcomes of Asian patients with atrial fibrillation: a report from the prospective APHRS-AF Registry.Scientific reports · 2023Article
- Sex differences involved in persistent atrial fibrillation recurrence after radiofrequency ablation.BMC cardiovascular disorders · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe risk of recurrence after atrial fibrillation (AF) catheter ablation (AFCA) is higher in women than in men. However, it is unknown whether a sex difference exists in antiarrhythmic drug (AAD) responsiveness among patients with recurrence.
methodsAmong 2999 consecutive patients (26.5% women, 58.3±10.9 years old, 68.1% paroxysmal AF) who underwent de novo AFCA, we compared and evaluated the sex differences in rhythm outcome in 1094 patients with recurrence and in 788 patients who subsequently underwent rhythm control with AAD.
resultsDuring a follow-up of 48.2±34.9 months, 1094 patients (36.5%) had AF recurrence after AFCA, and 508 of 788 patients (64.5%) had AF recurrence under AAD. Although the rhythm outcome of a de novo AFCA was worse (log-rank p=0.041, HR 1.28, 95% CI 1.02 to 1.59), p=0.031) in women, AAD response after postprocedural recurrences was better in women than in men (log-rank p=0.003, HR 0.75, 95% CI 0.59 to 0.95, p=0.022), especially in women older than 60 years old (log-rank p=0.003). In 249 patients who underwent repeat procedure after AAD use, the pulmonary vein (PV) reconnection rate (62.7% vs 76.8%, p=0.048) was lower in women than in men but not the existence of extra-PV trigger (37.8% vs 25.4%, p=0.169).
conclusionsAlthough women showed worse rhythm outcomes than men after AFCA, the post-AFCA AAD response was better in elderly women than in men. TRIAL REGISTRATION NUMBER: NCT02138695.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.