Evidence map›Paper›PMID 35332037›Full record

Observational studyBMJ open2022

Association between maternal adversity, DNA methylation, and cardiovascular health of offspring: a longitudinal analysis of the ALSPAC cohort study.

Natalie K Hyde, James G Dowty, Anna Scovelle, Gregory Armstrong, Georgina Sutherland, Lisa Olive, Kate Lycett, Adrienne O'Neil

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Natalie K HydeDeakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation,School of Medicine, Barwon Health, Geelong, VIC, Australia natalie.hyde@deakin.edu.au.ORCID 0000-0002-0693-2904
James G DowtyCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia.
Anna ScovelleCentre for Health Equity, Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.
Gregory ArmstrongCentre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-8073-9213
Georgina SutherlandCentre for Mental Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Lisa OliveDeakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation,School of Medicine, Barwon Health, Geelong, VIC, Australia.
Kate LycettSchool of Psychology, Deakin, Geelong, Victoria, Australia.
Adrienne O'NeilDeakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation,School of Medicine, Barwon Health, Geelong, VIC, Australia.

Funding

British Heart FoundationMedical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Wellcome Trust
6 · The paper itself

Abstract

objectivesMaternal adversity during pregnancy has been shown to be associated with some health outcomes in the offspring. This study investigated the association of maternal adversity during pregnancy and DNA methylation with offspring cardiovascular (CV) health.

designLongitudinal observational cohort study

settingAll pregnant residents in county Avon (∼0.9 million), UK, were eligible to participate if their estimated delivery date was between 1 April 1991 and 31 December 1992.

participantsMother-offspring pairs enrolled in the Avon Longitudinal Study of Parents and Children cohort at seven (n=7431) and 17 years of age (n=3143). PRIMARY AND SECONDARY OUTCOME MEASURES: Offspring CV health primary measures were heart rate (HR), blood pressure (BP) and secondary measures were pulse-wave velocity and carotid intima-media thickness.

resultsOverall, there was no association between maternal adversity scores (number or perceived impact) and primary CV measures (Perceived impact; HR: 0.999-fold change 95% CI 0.998 to 1.001; systolic BP (SBP): 1.000-fold change 95% CI 0.999 to 1.001; diastolic BP: 1.000-fold change 95% CI 0.999 to 1.002). Some small offspring sex effects were observed and there was also a small association between methylation of some CpG sites and offspring BP measures.

conclusionsWe found little evidence to support the overall association of maternal adversity during pregnancy and DNA methylation with offspring CV measures. Offspring sex-specific and age-specific associations require further investigation.

Indexed as

Carotid Intima-Media ThicknessDNA MethylationAdolescentBlood PressureChildCohort StudiesFemaleHumansLongitudinal StudiesMalePregnancycardiologyperinatologypsychiatry

Identifiers

PMID35332037
PMCPMC8948393

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