Evidence map›Paper›PMID 35332016›Full record

ArticleAJNR. American journal of neuroradiology2022

Third Trimester Structural and Diffusion Brain Imaging after Single Intrauterine Fetal Death in Monochorionic Twins: MRI-Based Cohort Study.

M Segev, B Djurabayev, E Hadi, Y Yinon, S Rabinowicz, C Hoffmann, S Shrot

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Fetal neurosurgery.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

M SegevFrom the Section of Neuroradiology (M.S., B.D., C.H., S.S.).ORCID 0000-0002-6684-1457
B DjurabayevFrom the Section of Neuroradiology (M.S., B.D., C.H., S.S.).ORCID 0000-0003-1204-1945
E HadiDivision of Diagnostic Imaging, Diagnostic Ultrasound Unit of the Institute of Obstetrical and Gynecological Imaging (E.H.).ORCID 0000-0002-5678-6802
Y YinonDepartment of Obstetrics and Gynecology, and Fetal Medicine Unit (Y.Y.), Department of Obstetrics and Gynecology, Sheba Medical Center, Ramat-Gan, Israel.ORCID 0000-0003-0702-370X
S RabinowiczPediatric Neurology Unit (S.R.), The Edmond and Lilly Safra Children's Hospital, Sheba Medical Center, Ramat Gan, Israel.ORCID 0000-0002-7111-035X
C HoffmannFrom the Section of Neuroradiology (M.S., B.D., C.H., S.S.).ORCID 0000-0002-5339-9495
S ShrotFrom the Section of Neuroradiology (M.S., B.D., C.H., S.S.) shai.shrot@sheba.health.gov.il.ORCID 0000-0001-8954-3244
Tel Aviv University · ILNeurology, Inc · USEdmond and Lily Safra Children's Hospital · ILImaging Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSingle intrauterine fetal death increases the risk of antenatal brain lesions in the surviving twin. We evaluated the prevalence of structural brain lesions, biometry, and diffusivity on routine third trimester MR imaging performed following single intrauterine fetal death. MATERIALS AND

methodsIn a retrospective MR imaging-based cohort study, we compared 29 monochorionic twins complicated with single intrauterine fetal death (14 following laser ablation treatment for twin-to-twin transfusion syndrome, 8 following selective fetal reduction, and 7 spontaneous) with 2 control cohorts (49 singleton fetuses and 28 uncomplicated twin fetuses). All fetuses in the single intrauterine fetal death group underwent fetal brain MR imaging as a routine third trimester evaluation. Structural brain lesions were analyzed. Cerebral biometry and diffusivity were measured and compared.

resultsBrain lesions consistent with the evolution of prior ischemic injury were found in 1 of 29 fetuses, not detected by ultrasound. No acute brain infarction, hemorrhage, or cortical abnormalities were found. Supratentorial biometric measurements in the single intrauterine fetal death group were significantly smaller than those in the singleton group, but not significantly different from those in the uncomplicated twin group. There were no significant differences in ADC values of the cerebral hemispheres, basal ganglia, and pons between the single intrauterine fetal death group and either control group.

conclusionsAlthough smaller brain biometry was found, normal diffusivity in surviving twins suggests normal parenchymal microstructure. The rate of cerebral structural injury was relatively low in our cohort, arguing against the routine use of fetal brain MR imaging in twin pregnancies complicated with single intrauterine fetal death. Larger prospective studies are necessary to guide appropriate surveillance protocol and parental counseling in twin pregnancies complicated by single intrauterine fetal death.

Indexed as

Brain InjuriesFetofetal TransfusionMagnetic Resonance ImagingBrainCohort StudiesFemaleFetal DeathHumansNeuroimagingPregnancyPregnancy Trimester, ThirdPregnancy, TwinProspective StudiesRetrospective StudiesTwins, MonozygoticUltrasonography, Prenatal

Identifiers

PMID35332016
PMCPMC8993195
OpenAlexW4220769153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.