Evidence map›Paper›PMID 35331871›Full record

ArticleNeuroImage2022

Subcortical segmentation of the fetal brain in 3D ultrasound using deep learning.

Linde S Hesse, Moska Aliasi, Felipe Moser, INTERGROWTH-21(st) Consortium, Monique C Haak, Weidi Xie, Mark Jenkinson, Ana I L Namburete

Abstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026
    Review
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  5. Deep learning assessment of fetal brain maturation on 3D ultrasound volumes in early-onset fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Linde S HesseInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, United Kingdom. Electronic address: linde.hesse@seh.ox.ac.uk.
Moska AliasiDepartment of Obstetrics and Fetal Medicine, Leiden University Medical Center, The Netherlands.
Felipe MoserDepartment of Computer Science, University of Oxford, United Kingdom.
INTERGROWTH-21(st) Consortium
Monique C HaakDepartment of Obstetrics and Fetal Medicine, Leiden University Medical Center, The Netherlands.
Weidi XieVisual Geometry Group, Department of Engineering Science, University of Oxford, United Kingdom.
Mark JenkinsonWellcome center for Integrative NeuroImaging, FMRIB, University of Oxford, United Kingdom; Australian Institute for Machine Learning (AIML), Australia; South Australian Health and Medical Research Institute (SAHMRI), Australia.
Ana I L NambureteDepartment of Computer Science, University of Oxford, United Kingdom.

Funding

Department of HealthWellcome Trust 203139/Z/16/Z
6 · The paper itself

Abstract

The quantification of subcortical volume development from 3D fetal ultrasound can provide important diagnostic information during pregnancy monitoring. However, manual segmentation of subcortical structures in ultrasound volumes is time-consuming and challenging due to low soft tissue contrast, speckle and shadowing artifacts. For this reason, we developed a convolutional neural network (CNN) for the automated segmentation of the choroid plexus (CP), lateral posterior ventricle horns (LPVH), cavum septum pellucidum et vergae (CSPV), and cerebellum (CB) from 3D ultrasound. As ground-truth labels are scarce and expensive to obtain, we applied few-shot learning, in which only a small number of manual annotations (n = 9) are used to train a CNN. We compared training a CNN with only a few individually annotated volumes versus many weakly labelled volumes obtained from atlas-based segmentations. This showed that segmentation performance close to intra-observer variability can be obtained with only a handful of manual annotations. Finally, the trained models were applied to a large number (n = 278) of ultrasound image volumes of a diverse, healthy population, obtaining novel US-specific growth curves of the respective structures during the second trimester of gestation.

Indexed as

Deep LearningBrainFemaleHumansImage Processing, Computer-AssistedNeural Networks, ComputerObserver VariationPregnancyUltrasonographyDeep learningFetal brainFew-Shot learningSegmentationSubcorticalUltrasound

Identifiers

PMID35331871
PMCPMC7618871

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.