Observational studyResuscitation2022
The association of modifiable mechanical ventilation settings, blood gas changes and survival on extracorporeal membrane oxygenation for cardiac arrest.
Observational study in Resuscitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of mechanical ventilation during v-a ecmo support: a systematic review.Critical care (London, England) · 2026Pooled it
- The extracorporeal cardiopulmonary resuscitation outcomes database.Resuscitation plus · 2026Article
- Acid-Base Status During Venoarterial Extracorporeal Membrane Oxygenator Support in Patients With Cardiogenic Shock.Journal of the American Heart Association · 2026Article
- Navigating the Evidence Gap: Expert Consensus as a Bridge to Research in Extracorporeal Cardiopulmonary Resuscitation for Adults.Journal of the American Heart Association · 2026Article
- Recommendations in Extracorporeal Cardiopulmonary Resuscitation Post Resuscitation Care Via An International, Modified Delphi Approach.Journal of the American Heart Association · 2026Review
- Differential biventricular responses to VA-ECMO flow ramping after cardiac arrest: establishment of a preclinical ECPR model with PV loop monitoring.Resuscitation plus · 2025Article
- Immediate post-ECPR management strategies in the prehospital and critical care transport medicine environments.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Review
- International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest: A Report From the National Heart, Lung, and Blood Institute Workshop.Journal of the American Heart Association · 2025Review
- Article
- Pulmonary Artery Pressures and Mortality During Venoarterial ECMO: An ELSO Registry Analysis.Circulation. Heart failure · 2024Article
- Oxygenation management during veno-arterial ECMO support for cardiogenic shock: a multicentric retrospective cohort study.Annals of intensive care · 2024Article
- Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest: an overview of current practice and evidence.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2024Review
- Wolf Creek XVII Part 7: Mechanical circulatory support.Resuscitation plus · 2023Review
- Extracorporeal membrane oxygenation for cardiac arrest: what, when, why, and how.Expert review of respiratory medicine · 2023Review
- How confidently can we prognosticate survival when starting ECPR?Resuscitation · 2023Article
- Benefits, key protocol components, and considerations for successful implementation of extracorporeal cardiopulmonary resuscitation: a review of the recent literature.Clinical and experimental emergency medicine · 2023Article
- Arterial oxygen and carbon dioxide tension and acute brain injury in extracorporeal cardiopulmonary resuscitation patients: Analysis of the extracorporeal life support organization registry.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Exposure to Arterial Hyperoxia During Extracorporeal Membrane Oxygenator Support and Mortality in Patients With Cardiogenic Shock.Circulation. Heart failure · 2023Article
- ECPR may be the most effective intervention for refractory cardiac arrest-ever.Resuscitation · 2022Article
- A qualitative analysis of physician decision making in the use of extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest.Resuscitation plus · 2022Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
research questionGiven the relative independence of ventilator settings from gas exchange and plasticity of blood gas values during extracorporeal cardiopulmonary resuscitation (ECPR), do mechanical ventilation parameters and blood gas values influence survival?
methodsObservational cohort study of 7488 adult patients with ECPR from the Extracorporeal Life Support Organization (ELSO) Registry. We performed case-mix adjustment for severity of illness and patient type using generalized estimating equation logistic regression to determine factors associated with hospital survival accounting for clustering by center, standardizing variables by 1 standard deviation (SD) of their values. We examined non-linear relationships between ventilatory and blood gas values with hospital survival.
resultsHospital survival was decreased with higher PaO
conclusionLower ventilatory pressures, avoidance of hyperoxia, and relatively unchanged CO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.