ReviewNeuropharmacology2022
Sex differences in pain along the neuraxis.
Review in Neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Sex-related analgesic responses to photobiomodulation therapy in rats with neuropathic pain.Lasers in medical science · 2026Article
- Muscle-Nerve Signaling and Neurogenic Inflammation in Temporomandibular Disorders: Potential Contributions of Occlusal Interference and Other Peripheral Triggers.Dentistry journal · 2026Review
- Article
- Sex-dependent central amygdala physiology after supradural CGRP exposure is associated with migraine-like behaviors.The journal of headache and pain · 2026Article
- Factors Associated with Pain, Disability, and Quality of Life in Adults Aged 18-65 with Nonspecific Chronic Neck Pain: A Single-Center Observational Study.Healthcare (Basel, Switzerland) · 2026Article
- Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations.Animal models and experimental medicine · 2026Review
- Recommendations for the inclusion and study of sex and gender in research.Nature neuroscience · 2026Review
- Sex-specific lateralization of the effects of exogenously-induced neuroimmune activation in the amygdala on pain-like behaviors.Frontiers in pharmacology · 2026Article
- Angiotensin II type 1 and type 2 receptors modulate TWIK1 channel expression and pain sensitivity in a rat model of neuropathic pain.Frontiers in pharmacology · 2026Article
- Sex-specific genetics underlie increased chronic pain risk in women: genome-wide association studies from the UK Biobank.British journal of anaesthesia · 2025Article
- Article
- Distribution and morphology of CGRP-IR axons in flat-mounts of whole male and female mouse atria.Autonomic neuroscience : basic & clinical · 2025Article
- Full-spectrum cannabis extracts for women with chronic pain syndromes: a real-life retrospective report of multi-symptomatic benefits after treatment with individually tailored dosage schemes.Frontiers in pharmacology · 2025Article
- Delineation of the trigeminal-lateral parabrachial-central amygdala tract in humans.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Factors associated with kinesiophobia among myocardial infarction survivors: a biopsychosocial perspective.Frontiers in psychiatry · 2025Article
- Review
- Sex Differences in Pain Scores and Medication Consumption for Chronic Non-Cancer Pain.Diseases (Basel, Switzerland) · 2024Article
- Article
- Article
- Cells and circuits for amygdala neuroplasticity in the transition to chronic pain.Cell reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Despite the overwhelming female-predominance in chronic pain disorders, preclinical pain studies have historically excluded females as research subjects. Male-biased explanations of pathological pain mechanisms may not fully translate to pain processes in females, necessitating the exploration of pain processing and modulation in both sexes at the preclinical and clinical levels. This review highlights historical trends in the study of sex differences within the pain field and examines the current literature regarding new techniques for the mechanistic analysis of pain modulation in males and females. A large body of evidence suggests that sex differences exist at the molecular, cellular, and systems levels of pain processing, likely influenced by a combination of genetic, hormonal, and neuroimmune factors that may differ at distinct levels of the neuraxis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.