ArticleGenetics in medicine : official journal of the American College of Medical Genetics2022
Implementation of preemptive DNA sequence-based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study.
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Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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42citing papers in PubMed, 1 pooled it
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacogenomics-assisted treatment versus standard of care in schizophrenia: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial.The pharmacogenomics journal · 2023Trial
- Integrating genomic medicine into primary care: a precision health model from Riyadh, Saudi Arabia.Family medicine and community health · 2026Article
- Multi-omics and artificial intelligence for precision drug discovery and potential clinical applications.Signal transduction and targeted therapy · 2026Review
- Actionable medications in Australian Vietnam War veterans: Implications for pre-emptive pharmacogenetic testing.Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists · 2026Article
- Pharmacotherapy Risks in Rare Genetic Diseases: Cross-Referencing ACMG Secondary Findings v3.2 List With Clinical Databases.Clinical and translational science · 2026Article
- Targeted adaptive sampling enables clinical pharmacogenomics testing and genome-wide genotyping.Scientific reports · 2025Article
- Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes.Annals of human genetics · 2025Review
- Patients' Concerns About Receiving Preemptive Pharmacogenomic Testing: Results from a Large, Longitudinal Survey of RIGHT Study Participants.Journal of personalized medicine · 2025Article
- Pharmacogenetic Testing in the Outpatient Setting in Switzerland: A Descriptive Study Using Swiss Claims Data.Drug safety · 2025Article
- Prevalence of Actionable Exposures to Pharmacogenetic Medications Among Solid Organ Transplant Recipients in a Population-Scale Biobank.Journal of personalized medicine · 2025Article
- Pharmacogenomic Testing in the Clinical Laboratory: Historical Progress and Future Opportunities.Annals of laboratory medicine · 2025Review
- Implementing CYP2C19-guided clopidogrel therapy: a scoping review of pharmacogenomic testing services.The pharmacogenomics journal · 2025Article
- Machine learning and multi-omics integration: advancing cardiovascular translational research and clinical practice.Journal of translational medicine · 2025Review
- Targeted Research and Treatment Implications in Women With Depression.Focus (American Psychiatric Publishing) · 2025Review
- A feasibility study on implementing pre-emptive pharmacogenomics testing in outpatient clinics in Singapore (IMPT study).The pharmacogenomics journal · 2025Article
- Implementation of pre-emptive testing of a pharmacogenomic panel in clinical practice: Where do we stand?British journal of clinical pharmacology · 2025Review
- Hypothesized pharmacogenomic and medication influences on tetrahydrocannabinol and cannabidiol metabolism in a cohort of unselected oral cannabis users.Journal of cannabis research · 2025Article
- The history and future of pharmacogenetics in Aotearoa/New Zealand.Journal of the Royal Society of New Zealand · 2025Review
- Pharmacogenomic augmented machine learning in electronic health record alerts: A health system-wide usability survey of clinicians.Clinical and translational science · 2024Article
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Authors and funding
122 authors.
Liewei WangCenter for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Clinical Pharmacology, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN.
Steven E SchererHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Suzette J BielinskiDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Donna M MuznyHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Leila A JonesCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
John Logan BlackDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Ann M MoyerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Jyothsna GiriCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Richard R SharpBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Eric T MateyDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Jessica A WrightDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Lance J OyenDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
Mathieu WiepertDepartment of Information Technology, Mayo Clinic, Rochester, MN.
Terri SullardCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Timothy B CurryCenter for Individualized Medicine, Mayo Clinic, Rochester, MN; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN.
Carolyn R Rohrer VitekCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Tammy M McAllisterCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Jennifer L St SauverDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
Pedro J CaraballoDivision of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Konstantinos N LazaridisCenter for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Eric VennerHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Xiang QinHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Jianhong HuHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Christie L KovarHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Viktoriya KorchinaHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Kimberly WalkerHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
HarshaVardhan DoddapaneniHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Tsung-Jung WuHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Ritika RajHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Shawn DensonHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Wen LiuHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Gauthami ChandanavelliHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Lan ZhangHuman Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX.
Qiaoyan WangHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Divya KalraHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Mary Beth KarowDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Kimberley J HarrisDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Hugues SicotteDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Sandra E PetersonDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Amy E BarthelDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Brenda E MooreDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Jennifer M SkierkaDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Michelle L KlugeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Katrina E KotzerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Karen KlokeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Jessica M Vander PolDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Heather MarkerCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Joseph A SuttonDepartment of Information Technology, Mayo Clinic, Rochester, MN.
Adrijana KekicDepartment of Pharmacy, Mayo Clinic, Phoenix, AZ.
Ashley EbenhohDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Dennis M BierleDivision of General Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Michael J SchuhDepartment of Pharmacy, Mayo Clinic, Jacksonville, FL.
Christopher GrilliDepartment of Pharmacy, Mayo Clinic, Phoenix, AZ.
Sara EricksonSupply Chain Management, Mayo Clinic, Rochester, MN.
Audrey UmbreitDepartment of Pharmacy, Mayo Clinic Health System, Mankato, MN.
Leah WardDepartment of Pharmacy, Mayo Clinic, Jacksonville, FL.
Sheena CrosbyDepartment of Pharmacy, Mayo Clinic, Jacksonville, FL.
Eric A NelsonDepartment of Pharmacy, Mayo Clinic, Phoenix, AZ.
Sharon LeveyDepartment of Clinical Genomics, Mayo Clinic, Scottsdale, AZ.
Michelle ElliottDivision of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Steve G PetersDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Naveen PereiraDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Mark FryeDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
Fadi ShamounDepartment of Cardiovascular Medicine, Mayo Clinic, Phoenix, AZ.
Matthew P GoetzDivision of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN.
Iftikhar J KulloDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Robert WermersDivision of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Jan A AndersonDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Christine M FormeaDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Razan M El MelikDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
John D ZeuliDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Joseph R HergesDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Carrie A KriegerDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Robert W HoelDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Jodi L TarabaDepartment of Pharmacy, Mayo Clinic, Rochester, MN.
Scott R St ThomasCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Imad AbsahDivision of Pediatric Gastroenterology and Hepatology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN.
Matthew E BernardDepartment of Family Medicine, Mayo Clinic, Rochester, MN.
Stephanie R FinkDivision of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Andrea GossardDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Pamela L GrubbsDepartment of Nursing, Mayo Clinic, Rochester, MN.
Therese M JacobsonDepartment of Nursing, Mayo Clinic, Rochester, MN.
Paul TakahashiDivision of Community Internal Medicine, Department of Internal Medicine, Mayo Clinic, Rochester, MN.
Sharon C ZeheLegal Department, Mayo Clinic, Rochester, MN.
Susan BucklesDepartment of Public Affairs, Mayo Clinic, Rochester, MN.
Michelle BumgardnerDepartment of Nursing, Mayo Clinic, Rochester, MN.
Colette GallagherDepartment of Public Affairs, Mayo Clinic, Rochester, MN.
Kelliann Fee-SchroederCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Nichole R NicholasCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Melody L PowersBiospecimens Accessioning and Processing Laboratory, Mayo Clinic, Rochester, MN.
Ahmed K RagabCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Darcy M RichardsonCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Anthony StaiDepartment of Information Technology, Mayo Clinic, Rochester, MN.
Jaymi WilsonCenter for Individualized Medicine, Mayo Clinic, Rochester, MN.
Joel E PacynaBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Janet E OlsonDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Erica J SuttonBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Annika T BeckBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Caroline HorrowBiomedical Ethics Research Program, Mayo Clinic, Rochester, MN.
Krishna R KalariDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Nicholas B LarsonDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Hongfang LiuDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN.
Liwei WangDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN.
Guilherme S LopesDivision of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Bijan J BorahRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN; Division of Health Care Policy and Research, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Robert R FreimuthDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN.
Ye ZhuRobert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, MN.
Debra J JacobsonDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Matthew A HathcockDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Sebastian M ArmasuDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Michaela E McGreeDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Ruoxiang JiangDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN.
Tyler H KoepOneOme, LLC, Minneapolis, MN.
Jason L RossOneOme, LLC, Minneapolis, MN.
Matthew G HildenOneOme, LLC, Minneapolis, MN.
Kathleen BosseOneOme, LLC, Minneapolis, MN.
Bronwyn RameyOneOme, LLC, Minneapolis, MN.
Isabelle SearcyOneOme, LLC, Minneapolis, MN.
Eric BoerwinkleHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Human Genome Sequencing Center Clinical Laboratory, Baylor College of Medicine, Houston, TX; School of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, TX.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX. Electronic address: agibbs@bcm.edu.
Richard M WeinshilboumCenter for Individualized Medicine, Mayo Clinic, Rochester, MN; Division of Clinical Pharmacology, Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN. Electronic address: weinshilboum.richard@mayo.edu.
Funding
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5MPharmacogenetics of Phase II Drug Metabolizing EnzymesU19GM061388 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 2010 to 2014
$15.8MRochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5MINHERITED VARIATIONS IN DRUG-METABOLIZING ENZYMESR01GM028157 · NIGMS · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 1985 to 2019
$6.9MInterdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4MPharmacogenomics of Breast Cancer Adjuvant ChemotherapyU01HG005137 · NHGRI · MAYO CLINIC ROCHESTER · PI WEINSHILBOUM, RICHARD M. · 2009 to 2011
$2.1MPharmacogenomic regulation of CYP transcription by TSPYL genesR01GM125633 · NIGMS · MAYO CLINIC ROCHESTER · PI WANG, LIEWEI · 2018 to 2021
$1.2MNHGRI NIH HHS U01 HG005137NHGRI NIH HHS U01 HG006379NIA NIH HHS R01 AG034676NIA NIH HHS R33 AG058738NIGMS NIH HHS R01 GM028157NIGMS NIH HHS R01 GM125633NIGMS NIH HHS U19 GM061388
Abstract
purposeThe Mayo-Baylor RIGHT 10K Study enabled preemptive, sequence-based pharmacogenomics (PGx)-driven drug prescribing practices in routine clinical care within a large cohort. We also generated the tools and resources necessary for clinical PGx implementation and identified challenges that need to be overcome. Furthermore, we measured the frequency of both common genetic variation for which clinical guidelines already exist and rare variation that could be detected by DNA sequencing, rather than genotyping.
methodsTargeted oligonucleotide-capture sequencing of 77 pharmacogenes was performed using DNA from 10,077 consented Mayo Clinic Biobank volunteers. The resulting predicted drug response-related phenotypes for 13 genes, including CYP2D6 and HLA, affecting 21 drug-gene pairs, were deposited preemptively in the Mayo electronic health record.
resultsFor the 13 pharmacogenes of interest, the genomes of 79% of participants carried clinically actionable variants in 3 or more genes, and DNA sequencing identified an average of 3.3 additional conservatively predicted deleterious variants that would not have been evident using genotyping.
conclusionImplementation of preemptive rather than reactive and sequence-based rather than genotype-based PGx prescribing revealed nearly universal patient applicability and required integrated institution-wide resources to fully realize individualized drug therapy and to show more efficient use of health care resources.
Indexed as
Cytochrome P-450 CYP2D6PharmacogeneticsAcademic Medical CentersBase SequenceGenotypeHumansCytochrome P-450 CYP2D6Clinical translationImplementationIndividualized medicinePharmacogenomicsPre-emptive clinical DNA sequencing
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