Evidence map›Paper›PMID 35331332›Full record

ArticleCritical care (London, England)2022

Early prone positioning in acute respiratory distress syndrome related to COVID-19: a propensity score analysis from the multicentric cohort COVID-ICU network-the ProneCOVID study.

Christophe Le Terrier, Florian Sigaud, Said Lebbah, Luc Desmedt, David Hajage, Claude Guérin, Jérôme Pugin, Steve Primmaz, Nicolas Terzi, COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Revue des maladies respiratoires actualites · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 2 countries.

Christophe Le TerrierDivision of Intensive Care, Geneva University Hospitals and the University of Geneva Faculty of Medicine, Geneva, Switzerland.
Florian SigaudMedical Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France.
Said LebbahAP-HP, Département de Santé Publique, Centre de Pharmaco-épidémiologie, Paris, France.
Luc DesmedtMedical Intensive Care Unit, Nantes Hôtel-Dieu University Hospital, Nantes, France.
David HajageAP-HP, Département de Santé Publique, Centre de Pharmaco-épidémiologie, Paris, France.
Claude GuérinDivision of Intensive Care, Edouard Herriot University Hospital, Lyon, France.
Jérôme PuginDivision of Intensive Care, Geneva University Hospitals and the University of Geneva Faculty of Medicine, Geneva, Switzerland.
Steve PrimmazDivision of Intensive Care, Geneva University Hospitals and the University of Geneva Faculty of Medicine, Geneva, Switzerland.
Nicolas TerziMedical Intensive Care Unit, Grenoble Alpes University Hospital, Grenoble, France. nterzi@chu-grenoble.fr.ORCID 0000-0003-4036-6245
COVID-ICU Group on behalf of the REVA Network and the COVID-ICU Investigators
Université Grenoble Alpes · FRUniversity of Geneva · CHAssistance Publique – Hôpitaux de Paris · FRHospices Civils de Lyon · FRSorbonne Université · FRCentre Hospitalier Universitaire d'Angers · FRCentre Hospitalier Universitaire de Grenoble · FRInserm · FRRegenerative NanoMedicine · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). We evaluated the use and the impact of early PP on clinical outcomes in intubated patients hospitalized in intensive care units (ICUs) for COVID-19.

methodsAll intubated patients with ARDS due to COVID-19 were involved in a secondary analysis from a prospective multicenter cohort study of COVID-ICU network including 149 ICUs across France, Belgium and Switzerland. Patients were followed-up until Day-90. The primary outcome was survival at Day-60. Analysis used a Cox proportional hazard model including a propensity score.

resultsAmong 2137 intubated patients, 1504 (70.4%) were placed in PP during their ICU stay and 491 (23%) during the first 24 h following ICU admission. One hundred and eighty-one patients (36.9%) of the early PP group had a PaO

conclusionsIn a large multicentric international cohort of intubated ICU patients with ARDS due to COVID-19, PP has been used frequently as a main treatment. In this study, our data failed to show a survival benefit associated with early PP started within 24 h after ICU admission compared to PP after day-1 for all COVID-19 patients requiring invasive mechanical ventilation regardless of their severity.

Indexed as

COVID-19Respiratory Distress SyndromeCohort StudiesHumansIntensive Care UnitsProne PositionPropensity ScoreProspective StudiesAcute respiratory distress syndromeCOVID-19Intensive care unitIntubationMortalityProne position

Identifiers

PMID35331332
PMCPMC8944409
OpenAlexW4226061743

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.