Evidence map›Paper›PMID 35331320›Full record

ArticleArthritis research & therapy2022

Differences in topographical location of sacroiliac joint MRI lesions in patients with early axial spondyloarthritis and mechanical back pain.

Rosa Marie Kiil, Clara E Mistegaard, Anne Gitte Loft, Anna Zejden, Oliver Hendricks, Anne Grethe Jurik

Open access · goldAbstract read
In one paragraph

Article in Arthritis research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. When it is not sacroiliitis.Skeletal radiology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. The sacroiliac joint across ages - what is normal?Therapeutic advances in musculoskeletal disease · 2024
    Review
  9. MRI Findings in Axial Psoriatic Spondylarthritis.Diagnostics (Basel, Switzerland) · 2023
    Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rosa Marie KiilDepartment of Radiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, C105, 8200, Aarhus N, Denmark. rosand@rm.dk.ORCID 0000-0002-5537-200X
Clara E MistegaardInstitute of Regional Health Research, University of Southern Denmark, Winsloewparken 19, 5000, Odense C, Denmark.
Anne Gitte LoftDepartment of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 103, 8200, Aarhus N, Denmark.
Anna ZejdenDepartment of Radiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, C105, 8200, Aarhus N, Denmark.
Oliver HendricksInstitute of Regional Health Research, University of Southern Denmark, Winsloewparken 19, 5000, Odense C, Denmark.
Anne Grethe JurikDepartment of Radiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 35, C105, 8200, Aarhus N, Denmark.
University of Southern Denmark · DKAarhus University · DKAarhus University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly diagnostics of axial spondyloarthritis (axSpA) remains a challenge. Traditional imaging one-plane sacroiliac joint (SIJ) MRI assessment is used. By introducing a two-plane assessment system, the objective was to analyse the differences in SIJ MRI changes in early axSpA compared with changes in patients with mechanical back pain (MBP) by exploring the differences in volume and location.

methodsMRIs in the early diagnostic state of 25 axSpA patients (mean age 31.3 years) and 59 MBP patients (mean age 32.3 years) were included. The MRIs were assessed by two readers regarding the distribution of bone marrow edema (BME) in 14 joint portions and structural changes in six joint portions in addition to SIJ anatomical variations and lumbar spine disc degeneration.

resultsAxSpA patients had a significantly higher overall BME sumscore (volume) of 25.1 compared to MBP patients 6.8, p < 0.005. The MBP group had the highest prevalence (66%) and sumscore (5.7) in the middle anterior sacrum. The axSpA group had significantly higher prevalence and sumscores in all joint portions except the three cartilaginous anterior sacral joint portions, including the ligamentous compartments (prevalence 40-60% compared to 8-15%, p both < 0.005). The axSpA group had also a significantly higher prevalence of erosions and fatty marrow disposition, but there were no differences in the prevalence of anatomical variations except the bipartite iliac bony plate.

conclusionsAxSpA patients demonstrated a widespread distribution of both inflammatory and structural changes, including high BME occurrence in the ligamentous joint portions whereas patients with MBP had the highest occurrence of BME in the middle anterior sacrum. These findings may help differentiate axSpA patients from other back pain conditions in the early diagnostic phase.

Indexed as

Axial SpondyloarthritisBone Marrow DiseasesLow Back PainSpondylarthritisAdultBack PainEdemaHumansMagnetic Resonance ImagingSacroiliac JointBack painImagingMagnetic resonance imaging (MRI)Spondyloarthritis

Identifiers

PMID35331320
PMCPMC8944150
OpenAlexW4220762451

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.