ReviewCritical care (London, England)2022
The impact of acquired coagulation factor XIII deficiency in traumatic bleeding and wound healing.
Review in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Comparison of outcomes in autoimmune acquired factor XIII deficiency with and without underlying diseases: a systematic review.Journal of thrombosis and thrombolysis · 2026Pooled it
- Preparative leukapheresis impairs autologous donor hemostasis and platelet function.Research and practice in thrombosis and haemostasis · 2026Observational
- M.O.I.S.T. Concept for the Local Therapy of Chronic Wounds: An International Update.The international journal of lower extremity wounds · 2026Review
- Cumulative exposure to factor XIII deficiency during veno-arterial extracorporeal membrane oxygenation: a prospective cohort study.Critical care (London, England) · 2026Article
- Article
- Factor XIII Supplementation in Postpartum Hemorrhage: From Biological Rationale to Clinical Implementation.American journal of hematology · 2026Review
- A Case of Factor XIII Deficiency Identified by Recurrent Postoperative Bleeding After Tonsillectomy.Clinical case reports · 2026Article
- Low FXIII activity levels in patients with vascular anomalies, not in patients with trauma-induced coagulopathy.PloS one · 2026Article
- Robot-Assisted Total Gastrectomy for Juvenile Polyposis Syndrome-Associated Gastric Cancer Performed in a Patient with Factor XIII Deficiency: A Case Report.Surgical case reports · 2026Article
- Unlucky for some? Bleeding associated with factor XIII deficiency during extracorporeal membrane oxygenation.Research and practice in thrombosis and haemostasis · 2026Article
- Case Report: A hidden cause of severe hemorrhage: a diagnostic and therapeutic challenge.Frontiers in immunology · 2026Article
- Factor XIII Deficiency: A Review of Biology, Testing, and Treatment.Clinical hematology international · 2026Review
- Exploring factor XIII genetic diversity: a familial approach to inheritance and variation.Thrombosis journal · 2025Article
- Acquired factor XIII deficiency in adult patients during ECMO: a prospective observational study.Scientific reports · 2025Observational
- High prevalence of factor XIII deficiency and its association with bleeding in extracorporeal membrane oxygenation patients: an observational study from a prospectively compiled biobank.Research and practice in thrombosis and haemostasis · 2025Article
- [Diagnostics and management of perioperative bleeding disorders].Die Anaesthesiologie · 2025Review
- Exploiting the Molecular Properties of Fibrinogen to Control Bleeding Following Vascular Injury.International journal of molecular sciences · 2025Review
- Measurement of factor XIII for the diagnosis and management of deficiencies: insights from a retrospective review of 10 years of data on consecutive samples and patients.Research and practice in thrombosis and haemostasis · 2025Article
- Coagulation Factor XIII - Last to think about?Blood transfusion = Trasfusione del sangue · 2025Article
- Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation.Blood advances · 2024Article
Corrections and comments
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Authors and funding
12 authors at 12 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Factor XIII (FXIII) is a protein involved in blood clot stabilisation which also plays an important role in processes including trauma, wound healing, tissue repair, pregnancy, and even bone metabolism. Following surgery, low FXIII levels have been observed in patients with peri-operative blood loss and FXIII administration in those patients was associated with reduced blood transfusions. Furthermore, in patients with low FXIII levels, FXIII supplementation reduced the incidence of post-operative complications including disturbed wound healing. Increasing awareness of potentially low FXIII levels in specific patient populations could help identify patients with acquired FXIII deficiency; although opinions and protocols vary, a cut-off for FXIII activity of ~ 60-70% may be appropriate to diagnose acquired FXIII deficiency and guide supplementation. This narrative review discusses altered FXIII levels in trauma, surgery and wound healing, diagnostic approaches to detect FXIII deficiency and clinical guidance for the treatment of acquired FXIII deficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.