Evidence map›Paper›PMID 35331252›Full record

ArticleHealth and quality of life outcomes2022

Health-related quality of life in young adults born small for gestational age: a prospective cohort study.

Cathrin Vano Mehl, Ingrid Marie Husby Hollund, Johanne Marie Iversen, Stian Lydersen, Paul Jarle Mork, Eero Kajantie, Kari Anne I Evensen

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Article in Health and quality of life outcomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  5. Health-related quality of life in 205 children with arthrogryposis multiplex congenita.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cathrin Vano MehlDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway. cathrivm@stud.ntnu.no.ORCID http://orcid.org/0000-0003-2516-4960
Ingrid Marie Husby HollundDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
Johanne Marie IversenDepartment of Internal Medicine, Nordland Hospital Trust, Bodø, Norway.
Stian LydersenDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Paul Jarle MorkDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway.
Eero KajantieDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
Kari Anne I EvensenDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals born small for gestational age (SGA) have an increased risk of several adverse health outcomes, but their health-related quality of life (HRQoL) across young adulthood has yet to be studied. The main aim of this study was to investigate if being born SGA at term is associated with poor HRQoL at 32 years of age. A second aim was to explore longitudinal changes in HRQoL from age 20 to 32 years.

methodsIn the prospective NTNU Low Birth Weight in a Lifetime Perspective study, 56 participants born SGA and 68 non-SGA control participants completed the Short Form 36 Health Survey (SF-36) at age 32 years to assess HRQoL. The SF-36 was also administrated at age 20 and 28 years. Longitudinal changes in the eight SF-36 domains and the two component summaries from 20 to 32 years were analyzed by linear mixed models. In total, 82 adults born SGA and 98 controls participated at least once and were included in the longitudinal analyses.

resultsAt age 32 years the participants born SGA scored 14.8 (95% CI 4.7 to 25.3) points lower in the SF-36 role-physical domain compared with the control group, i.e. more problems with work or other daily activities due to physical health problems. The longitudinal analyses showed significant group differences from 20 to 32 years in the role-emotional domain, and in the physical and mental component summaries. Among participants born SGA, the physical component summary decreased from age 20 to 28 years (-3.2, 95% CI -5.0 to -1.8), while the mental component summary (6.0, 95% CI 2.9 to 8.6) and role-emotional domain score (19.3, 95% CI 9.9 to 30.3) increased, but there were no further changes from 28 to 32 years. There were no longitudinal changes in the control group from 20 to 32 years.

conclusionOverall, individuals born SGA at term reported similar HRQoL at age 32 years compared with non-SGA controls. Self-perceived mental health improved during young adulthood among individuals born SGA, while self-perceived physical health deteriorated. The latter findings warrant further investigation.

Indexed as

Infant, Small for Gestational AgeQuality of LifeAdultGestational AgeHumansInfant, NewbornMental HealthProspective StudiesYoung AdultHealth-related quality of lifeLongitudinalLong-term outcomeSelf-perceived health statusSF-36Small for gestational ageYoung adulthood

Identifiers

PMID35331252
PMCPMC8944049

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.