Evidence map›Paper›PMID 35331225›Full record

ReviewBMC veterinary research2022

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives.

Bruno Campos, Amy C Pickering, Lis Souza Rocha, Ananda Pereira Aguilar, Mary Hellen Fabres-Klein, Tiago Antônio de Oliveira Mendes, J Ross Fitzgerald, Andrea de Oliveira Barros Ribon

Open access · goldAbstract readReview
In one paragraph

Review in BMC veterinary research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 1 pooled it
37.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.

  1. Pooled it
  2. An underlying mechanism of bovine mastitis: PGEThe veterinary quarterly · 2026
    Article
  3. Article
  4. Biocontrol of Staphylococcus aureus in dairy products using lytic bacteriophage UHP46: efficacy in milk, cheese, and yogurt.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Danggui Buxue Decoction AttenuatesVeterinary sciences · 2026
    Article
  13. Article
  14. Microorganisms · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Population genomic variation inMicrobial genomics · 2026
    Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Bruno CamposDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Viçosa, Brazil.
Amy C PickeringThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Edinburgh, UK.
Lis Souza RochaDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Viçosa, Brazil.
Ananda Pereira AguilarDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Viçosa, Brazil.
Mary Hellen Fabres-KleinCentro de Ciências Biológicas e da Saúde, Universidade Federal do Oeste da Bahia, Barreiras, Bahia, Brazil.
Tiago Antônio de Oliveira MendesDepartamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Viçosa, Brazil.
J Ross FitzgeraldThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Edinburgh, UK. ross.fitzgerald@roslin.ed.ac.uk.ORCID http://orcid.org/0000-0002-9233-8468
Andrea de Oliveira Barros RibonThe Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Campus, Edinburgh, UK. abribon@ufv.br.
Universidade Federal de Viçosa · BRRoslin Institute · GBUniversidade Federal do Oeste da Bahia · BR

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20002174Biotechnology and Biological Sciences Research Council ISP2: BBS/E/D/20002173Wellcome TrustWellcome Trust 201531/Z/16/Z
6 · The paper itself

Abstract

Staphylococcus aureus is a leading cause of bovine mastitis worldwide. Despite some improved understanding of disease pathogenesis, progress towards new methods for the control of intramammary infections (IMI) has been limited, particularly in the field of vaccination. Although herd management programs have helped to reduce the number of clinical cases, S. aureus mastitis remains a major disease burden. This review summarizes the past 16 years of research on bovine S. aureus population genetics, and molecular pathogenesis that have been conducted worldwide. We describe the diversity of S. aureus associated with bovine mastitis and the geographical distribution of S. aureus clones in different continents. We also describe studies investigating the evolution of bovine S. aureus and the importance of host-adaptation in its emergence as a mastitis pathogen. The available information on the prevalence of virulence determinants and their functional relevance during the pathogenesis of bovine mastitis are also discussed. Although traits such as biofilm formation and innate immune evasion are critical for the persistence of bacteria, the current understanding of the key host-pathogen interactions that determine the outcome of S. aureus IMI is very limited. We suggest that greater investment in research into the genetic and molecular basis of bovine S. aureus pathogenesis is essential for the identification of novel therapeutic and vaccine targets.

Indexed as

Cattle DiseasesMastitis, BovineStaphylococcal InfectionsAnimalsCattleFemaleStaphylococcus aureusVirulence FactorsVirulence FactorsBovine mastitisClonal complexesPathogenesisStaphylococcus aureus

Identifiers

PMID35331225
PMCPMC8944054
OpenAlexW4220702126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.