Evidence map›Paper›PMID 35331154›Full record

ArticleBMC pregnancy and childbirth2022

Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity.

Christin W Waage, Ibrahim Mdala, Hein Stigum, Anne Karen Jenum, Kåre I Birkeland, Nilam Shakeel, Trond M Michelsen, Kåre R Richardsen, Line Sletner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Lipid Profile and Management of Dyslipidemias in Pregnancy.Journal of cardiovascular development and disease · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Circadian Regulation of Lipid Metabolism during Pregnancy.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Christin W WaageGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Blindern, Post Box 1130, N-0318, Oslo, Norway. christin.waage@medisin.uio.no.
Ibrahim MdalaGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Blindern, Post Box 1130, N-0318, Oslo, Norway.
Hein StigumGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Blindern, Post Box 1130, N-0318, Oslo, Norway.
Anne Karen JenumGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Blindern, Post Box 1130, N-0318, Oslo, Norway.
Kåre I BirkelandInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Nilam ShakeelGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of Oslo, Blindern, Post Box 1130, N-0318, Oslo, Norway.
Trond M MichelsenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Kåre R RichardsenDepartment of Physiotherapy, Oslo Metropolitan University, Oslo, Norway.
Line SletnerInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
University of Oslo · NOAkershus University Hospital · NOOsloMet – Oslo Metropolitan University · NOOslo University Hospital · NO

Funding

EkstraStiftelsen Helse og Rehabilitering 2019/FO 244841
6 · The paper itself

Abstract

backgroundTo describe ethnic differences in concentrations of lipids and lipoproteins, and their changes, during pregnancy to postpartum.

methodsThis was a population-based cohort study conducted in primary antenatal care in Norway. The participants (n = 806) were healthy, pregnant women, 59% were ethnic minorities. Outcomes were triglycerides, total cholesterol, HDL- and LDL-cholesterol, analysed from fasting blood samples drawn at gestational age (weeks) 15, 28 and 14 weeks postpartum. We performed linear regression models and linear mixed models to explore the total effect of ethnicity on the outcomes, adjusting for gestational age /week postpartum, maternal age and education. The analyses are corrected for multiple testing using the Bonferroni correction.

resultsAt gestational age 15, triglyceride concentrations were lower in women of African origin (1.03 mmol/mol (95% CI: 0.90, 1.16)) and higher in women of South Asian (primarily Pakistan and Sri Lanka) origin (1.42 mmol/mol (1.35, 1.49)) and East Asian (primarily Vietnam, Philippines and Thailand) origin (1.58 mmol/mol (1.43, 1.73)) compared with Western Europeans (1.26 mmol/mol (1.20, 1.32)). Women of Asian and African origin had a smaller increase in triglycerides, LDL- and total cholesterol from gestational age 15 to 28. At gestational age 28, LDL-cholesterol levels were lowest among East Asians (3.03 mmol/mol (2.72, 3.34)) compared with Western Europeans (3.62 mmol/mol (3.50, 3.74)). Triglycerides and HDL-cholesterol were lower postpartum than at gestational age 15 in all groups, but the concentration of LDL-cholesterol was higher, except in Africans. South and East Asian women had lower HDL-cholesterol and higher triglycerides postpartum, while African women had lower triglycerides than Western Europeans.

conclusionWe found significant differences in the concentrations of lipids and lipoproteins and their changes during pregnancy and the early postpartum period related to ethnic origin.

Indexed as

EthnicityLipidsLipoproteinsPregnancyAdolescentAdultCholesterol, HDLCohort StudiesFemaleHumansTriglyceridesYoung AdultCholesterol, HDLLipidsLipoproteinsTriglyceridesEthnicityLipidsPostpartumPregnancy

Identifiers

PMID35331154
PMCPMC8953044
OpenAlexW4221110092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.