ArticleFunction (Oxford, England)2021
Role of Renal Sympathetic Nerve Activity in Volatile Anesthesia's Effect on Renal Excretory Function.
Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Dexmedetomidine May Reduce the Incidence of Acute Kidney Injury in Elderly Patients Undergoing Orthopedic Surgery: A Randomized, Double-Blind Clinical Trial.Drug design, development and therapy · 2026Trial
- Comparison of Effect Sevoflurane-Based Anesthesia and Propofol-Based Anesthesia on the Early Postoperative Renal Function of Living Kidney Transplant Donors: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Effects of Sevoflurane Versus Propofol Total Intravenous Anaesthesia on Renal Function in Elderly Patients Undergoing Hip Fracture Surgery: A Randomised Controlled Trial.Drug design, development and therapy · 2025Trial
- Do volatile anaesthetics depress urine output?Anaesthesiology intensive therapy · 2024Trial
- What is the significance of intra-operative oliguria with regard to post-operative acute kidney injury? A physiology-informed framework for intra-operative oliguria management.Journal of anesthesia, analgesia and critical care · 2026Review
- Interpreting perioperative oliguria during sevoflurane anesthesia: excretory physiology, fluid responsiveness, and renal endpoints.Journal of anesthesia · 2026Review
- Acute kidney injury after propofol or sevoflurane anaesthesia for colorectal cancer surgery: a secondary analysis.Anaesthesia · 2026Article
- The physiologic power of fluid circulation and implications for fluid therapy.Frontiers in veterinary science · 2026Review
- Where does the fluid go?Annals of intensive care · 2025Review
- A Novel Catheter-Based Method for Denervation of Afferent Renal Nerves in Sheep.Cardiovascular engineering and technology · 2025Article
- The association between the gut microbiome and 24-h blood pressure measurements in the SCAPIS study.Communications medicine · 2025Article
- Review
- Mechanical circulatory support reduces renal sympathetic nerve activity in an ovine model of acute myocardial infarction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Exercise pressor reflex function is augmented in rats with chronic kidney disease.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Effects of Sevofurane versus Propofol Total Intravenous Anaesthesia on Renal Function in Elderly Patients Undergoing Hip Fracture Surgery: A Randomised Controlled Trial [Response to Letter].Drug design, development and therapy · 2025Article
- Perioperative fluid therapy in adults and children: a narrative review.Frontiers in medicine · 2025Review
- Anesthetic management of diabetic foot amputation in a patient with renal failure and maintenance hemodialysis: case report and short communication.American journal of translational research · 2025Article
- The Effects of Volatile Anesthetics on Renal Sympathetic and Phrenic Nerve Activity during Acute Intermittent Hypoxia in Rats.Biomedicines · 2024Article
- Meaning and Management of Perioperative Oliguria.Anesthesiology · 2024Article
- Effects of isoflurane anaesthesia depth and duration on renal function measured with [EJNMMI research · 2024Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of fluid balance is pivotal during surgery and anesthesia and affects patient morbidity, mortality, and hospital length of stay. Retention of sodium and water is known to occur during surgery but the mechanisms are poorly defined. In this study, we explore how the volatile anesthetic sevoflurane influences renal function by affecting renal sympathetic nerve activity (RSNA). Our results demonstrate that sevoflurane induces renal sodium and water retention during pediatric anesthesia in association with elevated plasma concentration of renin but not arginine-vasopressin. The mechanisms are further explored in conscious and anesthetized ewes where we show that RSNA is increased by sevoflurane compared with when conscious. This is accompanied by renal sodium and water retention and decreased renal blood flow (RBF). Finally, we demonstrate that renal denervation normalizes renal excretory function and improves RBF during sevoflurane anesthesia in sheep. Taken together, this study describes a novel role of the renal sympathetic nerves in regulating renal function and blood flow during sevoflurane anesthesia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.