Evidence map›Paper›PMID 35330743›Full record

ArticleFunction (Oxford, England)2020

Viewing Cortical Collecting Duct Function Through Phenotype-guided Single-Tubule Proteomics.

Nina Himmerkus, Samuel L Svendsen, Catarina Quintanova, Markus Bleich, Otto Von Schwerdtner, Thomas Benzing, Paul A Welling, Jens Leipziger, Markus M Rinschen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Function (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Functional Tissue Units in the Human Reference Atlas.bioRxiv : the preprint server for biology · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Nina HimmerkusInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.
Samuel L SvendsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Catarina QuintanovaInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.
Markus BleichInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.
Otto Von SchwerdtnerInstitute of Physiology, Christian Albrechts University Kiel, Kiel, Germany.
Thomas BenzingCenter for Molecular Medicine, University of Cologne, Cologne, Germany.
Paul A WellingDepartments of Physiology and Medicine, Johns Hopkins University, Baltimore, MD, USA.
Jens LeipzigerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Markus M RinschenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Kiel University · DEAarhus University · DKJohns Hopkins Medicine · USScripps Health · USUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The revolution of the omics technologies has enabled profiling of the molecules of any sample. However, the heterogeneity of the kidney with highly specialized nephron segments like the cortical collecting duct (CCD) poses a challenge regarding integration of omics data and functional analysis. We examined function and proteome from the same single CCDs of C57Bl6 mice by investigating them in a double-barreled perfusion system before targeted mass spectrometry. Transepithelial voltage (V

Indexed as

Kidney Tubules, CollectingAdenosine TriphosphatasesAnimalsAquaporin 2MiceMice, Inbred C57BLPhenotypeProteomeProteomicsSulfate TransportersAdenosine TriphosphatasesAquaporin 2ProteomeSulfate Transportersheterogeneityintercalated cellpendrinplasticityprincipal cellproteomicssalt- and water transport

Identifiers

PMID35330743
PMCPMC8788781
OpenAlexW3040263870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.