ReviewFrontiers in bioengineering and biotechnology2022
Ceramic Toughening Strategies for Biomedical Applications.
Review in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- When bioactivity comes at a mechanical cost: toward mechanically safe bioactivation of zirconia dental implants.Bioactive materials · 2027Review
- Strategic Placement of Pores to Modulate Toughness in Hydroxyapatite Bone Scaffolds Fixation.Biomimetics (Basel, Switzerland) · 2026Article
- PEEK in modern maxillofacial surgery: clinical applications, limitations and future opportunities.British dental journal · 2026Review
- Interphase-Centric and Mechanism-Driven Advances in Polymer Composites Reinforced with Nano-, Synthetic, and Inorganic Fillers.Polymers · 2026Review
- Effects of Repeated Use and Sterilization on the Wear of Zirconia Implant Drills: A SEM-Based Analysis.Clinical and experimental dental research · 2025Article
- Comparison of Biocompatibility of 3D-Printed Ceramic and Titanium in Micropig Ankle Hemiarthroplasty.Biomedicines · 2024Article
- Advances, Challenges, and Applications of Graphene and Carbon Nanotube-Reinforced Engineering Ceramics.Nanomaterials (Basel, Switzerland) · 2024Review
- Biomechanical behaviour of tilted abutment after fixed partial denture restoration of CAD/CAM materials.BMC oral health · 2024Article
- Bond strength of ceramic veneered CAD-milled alloy upon prolonged sintering.Clinical oral investigations · 2023Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Three-Dimensional-Printed Molds from Water-Soluble Sulfate Ceramics for Biocomposite Formation through Low-Pressure Injection Molding.Materials (Basel, Switzerland) · 2023Article
- Advancing herbal medicine: enhancing product quality and safety through robust quality control practices.Frontiers in pharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aiming at shortage of metal materials, ceramic is increasingly applied in biomedicine due to its high strength, pleasing esthetics and good biocompatibility, especially for dental restorations and implants, artificial joints, as well as synthetic bone substitutes. However, the inherent brittleness of ceramic could lead to serious complications, such as fracture and disfunction of biomedical devices, which impede their clinical applications. Herein, several toughening strategies have been summarized in this review, including reinforcing phase addition, surface modification, and manufacturing processes improvement. Doping metal and/or non-metal reinforcing fillers modifies toughness of bulk ceramic, while surface modifications, mainly coating, chemical and thermal methods, regulate toughness on the surface layer. During fabrication, optimization should be practiced in powder preparation, green forming and densification processes. Various toughening strategies utilize mechanisms involving fine-grained, stress-induced phase transformation, and microcrack toughening, as well as crack deflection, bifurcation, bridging and pull-out. This review hopes to shed light on systematic combination of different toughening strategies and mechanisms to drive progress in biomedical devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.