Evidence map›Paper›PMID 35330585›Full record

ArticleFrontiers in medicine2022

A Longitudinal Analysis of SARS-CoV-2 Antibody Responses Among People With HIV.

Maria L Alcaide, Nicholas F Nogueira, Ana S Salazar, Emily K Montgomerie, Violeta J Rodriguez, Patricia D Raccamarich, Irma T Barreto, Angela McGaugh, Mark E Sharkey, Alejandro M Mantero and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Maria L AlcaideDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Nicholas F NogueiraDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Ana S SalazarDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Emily K MontgomerieDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Violeta J RodriguezDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States.
Patricia D RaccamarichDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Irma T BarretoDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Angela McGaughDepartment of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Mark E SharkeyDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Alejandro M ManteroDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, United States.
Allan E RodriguezDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Laura BeauchampsDivision of Infectious Diseases, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Deborah L JonesDepartment of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, United States.
University of Miami · US

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ALLAN E RODRIGUEZ · 2007 to 2026
$33.8M
NIAID NIH HHS P30 AI073961
6 · The paper itself

Abstract

Background: The concentration and duration of antibodies (Ab) to SARS-CoV-2 infection predicts the severity of the disease and the clinical outcomes. Older people and those with HIV have impaired immune responses, worse outcomes after SARS-CoV-2 infection, and lower antibody responses after viral infection and vaccination. This study evaluated an Ab response to SARS-CoV-2 in people with HIV (PWH) and without HIV (HIV-) and its association with age. Methods: A total of 23 COVID+PWH and 21 COVID+HIV- participants were followed longitudinally for 6 months post-mild COVID-19. Immunoglobin G (IgG) and immunoglobin M (IgM) Ab responses were measured by an in-house developed ELISA. Time points and HIV status interaction were analyzed using Poisson generalized estimating equations, and correlations were analyzed using non-parametric tests. Results: Median age in PWH was 55 years with 28.6% women, while in the HIV- group was 36 years with 60.9% women. The mean time from COVID-19 diagnosis to study enrollment was 16 days for PWH and 11 days for HIV-. The mean CD4+ T-cell count/μl for PWH was 772.10 (±365.21). SARS-CoV-2 IgM and IgG were detected at all time points and Ab response levels did not differ by HIV status ( Conclusion: The Ab responses in the 6-month post-SARS-CoV-2 infection did not differ by HIV status, though a positive association was found between age and Ab response in older PWH. Results suggest that immune protection and vaccine responses are similar for PWH than for those without HIV infection.

Indexed as

adaptive immunityantibodyCOVID-19 vaccineHIVinnate immunitySARS-CoV-2

Identifiers

PMID35330585
PMCPMC8940197
OpenAlexW4220988106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.