Evidence map›Paper›PMID 35330402›Full record

ReviewJournal of personalized medicine2022

Radiogenomic Predictors of Recurrence in Glioblastoma-A Systematic Review.

Felix Corr, Dustin Grimm, Benjamin Saß, Mirza Pojskić, Jörg W Bartsch, Barbara Carl, Christopher Nimsky, Miriam H A Bopp

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Multimodal MRI andDiagnostics (Basel, Switzerland) · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Felix CorrDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0002-5365-7511
Dustin GrimmDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0003-2664-3568
Benjamin SaßDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0003-2855-3443
Mirza PojskićDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Jörg W BartschDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0002-2773-3357
Barbara CarlDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Christopher NimskyDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0002-8216-9410
Miriam H A BoppDepartment of Neurosurgery, University of Marburg, Baldingerstrasse, 35043 Marburg, Germany.ORCID 0000-0003-1574-7572

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma, as the most aggressive brain tumor, is associated with a poor prognosis and outcome. To optimize prognosis and clinical therapy decisions, there is an urgent need to stratify patients with increased risk for recurrent tumors and low therapeutic success to optimize individual treatment. Radiogenomics establishes a link between radiological and pathological information. This review provides a state-of-the-art picture illustrating the latest developments in the use of radiogenomic markers regarding prognosis and their potential for monitoring recurrence. Databases PubMed, Google Scholar, and Cochrane Library were searched. Inclusion criteria were defined as diagnosis of glioblastoma with histopathological and radiological follow-up. Out of 321 reviewed articles, 43 articles met these inclusion criteria. Included studies were analyzed for the frequency of radiological and molecular tumor markers whereby radiogenomic associations were analyzed. Six main associations were described: radiogenomic prognosis, MGMT status, IDH, EGFR status, molecular subgroups, and tumor location. Prospective studies analyzing prognostic features of glioblastoma together with radiological features are lacking. By reviewing the progress in the development of radiogenomic markers, we provide insights into the potential efficacy of such an approach for clinical routine use eventually enabling early identification of glioblastoma recurrence and therefore supporting a further personalized monitoring and treatment strategy.

Indexed as

GBMglioblastomagliomasimaging genomicsmagnetic resonance imagingmolecular markersneuro-oncologyradiogenomicsradiologyradiomicsrecurrence

Identifiers

PMID35330402
PMCPMC8952807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.