Evidence map›Paper›PMID 35330334›Full record

ArticleJournal of personalized medicine2022

Patient and Physician Preferences for Regimen Attributes for the Treatment of HIV in the United States and Canada.

Heather Gelhorn, Cindy Garris, Erin Arthurs, Frank Spinelli, Katelyn Cutts, Gin Nie Chua, Hannah Collacott, Bertrand Lebouché, Erik Lowman, Howard Rice and 1 more

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. "What Is the Benefit?": Perceptions and Preferences for Long-Acting Injectable Antiretroviral Therapy Among People Living With HIV.AIDS education and prevention : official publication of the International Society for AIDS Education · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heather GelhornEvidera, Bethesda, MD 20814, USA.ORCID 0000-0003-3566-1004
Cindy GarrisUS Health Outcomes, ViiV Healthcare, Research Triangle Park, NC 27709, USA.ORCID 0000-0002-2685-1204
Erin ArthursGlaxoSmithKline, Mississauga, ON L5N 6L4, Canada.
Frank SpinelliNorth American Medical Affairs, ViiV Healthcare, Research Triangle Park, NC 27709, USA.
Katelyn CuttsEvidera, Bethesda, MD 20814, USA.
Gin Nie ChuaEvidera, London W6 8BJ, UK.
Hannah CollacottEvidera, London W6 8BJ, UK.
Bertrand LebouchéCentre for Outcomes Research & Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC H3H 2R9, Canada.ORCID 0000-0002-1273-9393
Erik LowmanMidland Medical Center, Oakland Park, FL 33334, USA.
Howard RiceRice Medical Group, Mountain View, CA 94040, USA.
Sebastian HeidenreichEvidera, London W6 8BJ, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A long-acting injectable (LAI) antiretroviral therapy (ART) regimen is now available as a treatment option for virologically suppressed adults with HIV-1. This study assessed preference for a LAI regimen using an online survey of virally suppressed people living with HIV (PLWH) and physicians treating HIV in the US and Canada. Preference was elicited in a discrete choice experiment (DCE) with three choice options (switch to a LAI regimen, switch to another daily oral ART regimen, or stay on their current daily oral ART regimen) and four treatment attributes. A total of 553 PLWH and 450 physicians completed the survey. From the DCE results, 59% of PLWH were predicted to prefer a LAI over an alternative oral ART or staying on their current oral treatment, and 55-66% of physicians were predicted to recommend LAI for PLWH, depending on the treatment challenge scenario presented. PLWH indicated LAI would remove daily reminders of HIV (75%) and reduce feelings of being stigmatized (68%). A majority of PLWH and physicians preferred a LAI over oral ART to overcome treatment challenges such as daily pill burden and adherence. These benefits of LAI ART along with preferences of PLWH and physicians can help to inform ART choice.

Indexed as

antiretroviral therapydiscrete choice experiment (DCE)HIVlong-acting injectable (LAI)patient preferencephysician preference

Identifiers

PMID35330334
PMCPMC8948790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.