Evidence map›Paper›PMID 35330188›Full record

ReviewLife (Basel, Switzerland)2022

Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation.

Katie A O'Brien, Andrew J Murray, Tatum S Simonson

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
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  6. Article
  7. Article
  8. Innovative approaches for the treatment of stroke: a recent update.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  9. Association of High-Altitude Polycythemia with JAK2V617F Mutation in Pakistani Population.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025
    Article
  10. Notch2 Inhibition and Kidney Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Katie A O'BrienDepartment of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.
Andrew J MurrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK.ORCID 0000-0002-0929-9315
Tatum S SimonsonDivision of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093, USA.

Funding

Respiratory and genomic contributions to adaptive/maladaptive hypoxia responsesR01HL145470 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2019 to 2023
$2.4M
Integrating physiology and genomics to reveal functional adaptation in high-altitK99HL118215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2014 to 2014
$85k
Marie Curie 890768NHLBI NIH HHS K99 HL118215NHLBI NIH HHS R01 HL145470
6 · The paper itself

Abstract

Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O

Indexed as

adaptationhypobaric hypoxiahypoxia-inducible factorNotch signaling

Identifiers

PMID35330188
PMCPMC8954738

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.