ArticleLife (Basel, Switzerland)2022
Piceatannol Affects Gastric Ulcers Induced by Indomethacin: Association of Antioxidant, Anti-Inflammatory, and Angiogenesis Mechanisms in Rats.
Article in Life (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Phytochemical-driven angiogenesis and mucosal regeneration in gastric ulcer healing: molecular mechanisms, preclinical evidence, and translational perspectives.Molecular biology reports · 2026Review
- Djulis beverage attenuates gastric mucosal injury by modulating oxidative stress and inflammation.NPJ science of food · 2026Article
- A comparative study of some NSAIDs with natural products: integrating in vitro anticancer efficacy, in vivo antiulcerative effect, histochemistry, and in silico analysis.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Syringic acid protects against indomethacin-induced gastric injury via NF-κB and apoptotic pathway modulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect of piceatannol on rheumatoid arthritis.Frontiers in immunology · 2026Article
- The synergistic protective effects of bioactive catechins in longjing tea: alleviate indomethacin-induced gastric toxicity through modulation of inflammatory and apoptotic pathways.Frontiers in pharmacology · 2026Article
- Myricetin alleviates indomethacin-induced gastric ulcers in rats via antioxidant, anti-inflammatory and antiapoptotic mechanisms.Inflammopharmacology · 2025Article
- Kombucha Prevents Indomethacin-Induced Enteric Damage in Wistar Rat by Enhancing Epithelial Gut Barrier and Modulating Gut Microbiota.Food science & nutrition · 2025Article
- Unlocking Gut Health: The Potent Role of Stilbenoids in Intestinal Homeostasis.Animals : an open access journal from MDPI · 2025Review
- Troxerutin effect on gastric ulcers induced by ketorolac in rats: Relation with oxidative stress.Heliyon · 2024Article
- Parthenolide alleviates indomethacin-induced gastric ulcer in rats via antioxidant, anti-inflammatory, and antiapoptotic activities.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study.Journal of molecular histology · 2024Article
- Article
- Gastroprotective Effect of 2,3-Dimethylquinoxaline Against Indomethacin-Induced Gastric Ulcer in Rat.Journal of inflammation research · 2024Article
- Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats.Inflammopharmacology · 2023Article
- Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives.Scientific reports · 2023Article
- Chitosan-Polyphenol Conjugates for Human Health.Life (Basel, Switzerland) · 2022Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
One of the major aggressive factors that affect gastric injury is non-steroidal anti-inflammatory drugs (NSAIDs). Indomethacin (Indo) showed higher potentiality in gastric injury over conventional NSAIDs. Piceatannol (PIC) is a natural polyphenolic stilbene that possesses potent antioxidant and anti-inflammatory properties. The gastroprotective properties of PIC have been overlooked previously. Hence, we aim to study gastric injury induced by Indo and the protective action manifested by PIC, as well as to elucidate the likely underlying mechanisms of action in a rat model. The rats have been treated with vehicle, Indo alone, combined treatment with Indo, and PIC at (5 mg/kg or 10 mg/kg), respectively. The rats were also treated with Indo and omeprazole. In our study, we found that PIC at both 5 and 10 mg/kg doses was effective by averting the rise in ulcer and lesion indices, acid production, and histological variations persuaded by Indo. Mechanistically, PIC significantly reduced lipid peroxidation product (MDA), increased the GSH content, and enhanced SOD and CAT activity. In addition, PIC exhibits a distinct reduction in the levels of inflammatory parameters (Cox-2, IL-6, TNF-α, and NFκB). Contrastingly, PIC augmented both mucin and PGE2 content. Moreover, PIC fostered angiogenesis by increasing the expression of proangiogenic factors (VEGF, bFGF, and PDGF). Overall, the above results suggest PIC exhibits a potential protective effect against Indo-induced gastric ulcers by the antioxidant, anti-inflammatory, and angiogenic mechanisms.
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