Evidence map›Paper›PMID 35329513›Full record

ArticleMaterials (Basel, Switzerland)2022

Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma.

Chaochao Zhao, Yuan Yang, Xi Cui, Yizhu Shan, Jiangtao Xue, Dongjie Jiang, Jinyan Sun, Na Li, Zhou Li, Anping Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Chaochao ZhaoDepartment of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China.ORCID 0000-0002-6698-241X
Yuan YangBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
Xi CuiBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
Yizhu ShanBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
Jiangtao XueBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
Dongjie JiangBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.
Jinyan SunDepartment of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China.
Na LiDepartment of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China.
Zhou LiBeijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China.ORCID 0000-0002-9952-7296
Anping YangDepartment of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China.
Chinese Academy of Sciences · CNFoshan University · CNBeijing Institute of Technology · CN

Funding

Beijing Natural Science Foundation JQ20038Foshan Bureau of Finance: Developmental and Applied Basic Research of Advanced Technology in Stomatology CGQ020Guangdong Basic and Applied Basic Research Foundation 2019A1515110639, 2019A1515110013Key Platform and Scientific Research Project of Guangdong Provincial Education Department 2018KTSCX246National Natural Science Foundation of China 82001981, T2125003, 61875015Scientific Research Foundation for Advanced Scholars of Foshan University Gg07247, Gg07164
6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is a common oral cancer of the head and neck, which causes tremendous physical and mental pain to people. Traditional chemotherapy usually results in drug resistance and side effects, affecting the therapy process. In this study, a self-powered electrical impulse chemotherapy (EIC) method based on a portable triboelectric nanogenerator (TENG) was established for OSCC therapy. A common chemotherapeutic drug, doxorubicin (DOX), was used in the experiment. The TENG designed with zigzag structure had a small size of 6 cm × 6 cm, which could controllably generate the fixed output of 200 V, 400 V and 600 V. The electrical impulses generated by the TENG increased the cell endocytosis of DOX remarkably. Besides, a simply and ingeniously designed microneedle electrode increased the intensity of electric field (EF) between two adjacent microneedle tips compared with the most used planar interdigital electrode at the same height, which was more suitable for three-dimensional (3D) cells or tissues. Based on the TENG, microneedle electrode and DOX, the self-powered EIC system demonstrated a maximal apoptotic cell ratio of 22.47% and a minimum relative 3D multicellular tumor sphere (MCTS) volume of 160% with the drug dosage of 1 μg mL

Indexed as

electrical impulse chemotherapyoral squamous cell carcinomaself-poweredtriboelectric nanogenerator

Identifiers

PMID35329513
PMCPMC8954269
OpenAlexW4220838275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.