Evidence map›Paper›PMID 35329310›Full record

ArticleInternational journal of environmental research and public health2022

Peri-Implant Surgical Treatment Downregulates the Expression of sTREM-1 and MMP-8 in Patients with Peri-Implantitis: A Prospective Study.

Glaucia Schuindt Teixeira Neves, Gayathiri Elangovan, Mayla Kezy Silva Teixeira, João Martins de Mello-Neto, Santosh Kumar Tadakamadla, Eduardo José Veras Lourenço, Daniel Moraes Telles, Carlos Marcelo Figueredo

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Glaucia Schuindt Teixeira NevesDepartment of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil.
Gayathiri ElangovanSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.ORCID 0000-0001-8858-639X
Mayla Kezy Silva TeixeiraDepartment of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil.ORCID 0000-0003-2356-5787
João Martins de Mello-NetoSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.
Santosh Kumar TadakamadlaSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.
Eduardo José Veras LourençoDepartment of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil.
Daniel Moraes TellesDepartment of Prosthodontics, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil.ORCID 0000-0001-9576-4342
Carlos Marcelo FigueredoSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland 4222, Australia.ORCID 0000-0003-0222-9231
Griffith University · AUUniversidade do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

sTREM-1 and its ligand PGLYRP1 play an essential role in the inflammatory process around teeth and implants. In this study, we aimed to evaluate the impact of peri-implant treatment on the salivary levels of the sTREM-1/PGLYRP-1/MMP-8 axis after 3 months. A total of 42 participants (with a mean age of 61 years old ± 7.3) were enrolled in this longitudinal study, 24 having peri-implant mucositis (MU) and 18 having peri-implantitis (PI). Clinical peri-implant parameters, such as probing pocket depth (PPD), % of plaque, and bleeding on probing (BOP), and the whole unstimulated saliva samples were evaluated at baseline and 3 months after treatment. The MU group received nonsurgical peri-implant treatment, while the PI group received open-flap procedures. The levels of sTREM-1, PGLYRP-1, MMP-8, and TIMP-1 were analyzed using enzyme-linked immunosorbent assays. BOP, plaque levels, and PPD significantly reduced after treatment in both groups. A significant decrease in the salivary levels of sTREM-1, MMP-8, and TIMP-1 in the PI group and PGLYRP1 and TIMP-1 in the MU group were observed. Salivary levels of sTREM-1 were significantly reduced in patients with PI but not with MU. Additionally, peri-implant treatment had a significantly higher impact on MMP-8 reduction in patients with PI than in those with MU.

Indexed as

Matrix Metalloproteinase 8Peri-ImplantitisTriggering Receptor Expressed on Myeloid Cells-1AgedHumansLongitudinal StudiesMiddle AgedProspective StudiesTissue Inhibitor of Metalloproteinase-1Matrix Metalloproteinase 8MMP8 protein, humanTIMP1 protein, humanTissue Inhibitor of Metalloproteinase-1TREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1MMP-8peri-implantitisperi-implant mucositisperi-implant treatmentPGLYRP-1sTREM-1

Identifiers

PMID35329310
PMCPMC8955840
OpenAlexW4220786548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.