ReviewInternational journal of environmental research and public health2022
Premature Loss of Deciduous Teeth as a Symptom of Systemic Disease: A Narrative Literature Review.
Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Does the early loss of primary teeth impact the oral health-related quality of life of children? A systematic review and meta-analysis.Clinical oral investigations · 2025Pooled it
- Paediatric dental trauma: insights from epidemiological studies and management recommendations.BMC oral health · 2025Pooled it
- Examining the Role of Vitamin D in Caries Susceptibility in Children's Deciduous Teeth: A Systematic Review.Nutrients · 2023Pooled it
- Effectiveness of traditional band and loop space maintainer vs 3D-printed space maintainer following the loss of primary teeth: a randomized clinical trial.Scientific reports · 2024Trial
- The Relationship Between Neonatal and Maternal Factors and the Timing of Primary Tooth Eruption in Preterm Infants: An Observational Study in Iran.Health science reports · 2026Article
- Review
- Cytokines as Key Drivers of Pathological Root Resorption: Integrating Molecular Mechanisms, Genetic Determinants, and Biomarker-Based Insights.Biomedicines · 2026Review
- Challenges in Diagnosis and Management of Coffin-Lowry Syndrome-Single-Center Experience.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Functional and Organic Foods in Enhancing the Oral and Dental Health and Hygiene-A Comprehensive Review.Food science & nutrition · 2026Review
- A novel full digital workflow for dental autotransplantation: surgical accuracy and clinical outcomes in a prospective cohort study.Frontiers in oral health · 2026Article
- Assessment of the biomechanical performance of digitally manufactured space maintainers: a finite element analysis.Scientific reports · 2025Article
- Obturation of Primary Teeth: Time to Redefine Objectives and Techniques.International journal of clinical pediatric dentistry · 2025Article
- Association of Systemic Pathologies on Dental, Periodontal and Orthodontic Status in Children.Biomedicines · 2025Article
- Clinical and molecular results in 15 Turkish patients with Wiedemann-Steiner syndrome: identification of eight novel KMT2A variants and a case of dual molecular diagnosis in the CSNK2A1.European journal of pediatrics · 2025Article
- Barriers and challenges of mothers' participation in fluoride varnish program for children aged 3-6: A qualitative study.Journal of public health research · 2025Article
- A Case of Hypophosphatasia Started Enzyme Replacement Therapy Since Babyhood Stage.Children (Basel, Switzerland) · 2025Article
- Physiological Root Resorption of Deciduous Teeth: An ATR-FTIR Approach.Journal of clinical medicine · 2024Article
- Junaidi Space Regainer: A New Two-in-One Chairside Appliance to Simplify the Space Regaining Procedure.Cureus · 2024Article
- A retrospective study on the outcome of pulpotomy with iRoot BP plus in primary molars and its relationship with hemostasis time.BMC oral health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPremature loss of primary teeth can occur as a consequence of dental trauma, neonatal tooth extraction, early childhood caries, or periodontal problems, or it can be a manifestation of systemic disease. This review aims to present systemic disorders that can lead to premature loss of deciduous teeth in children and to provide a comprehensive resource for clinical practice for both physicians and dentists.
methodsThis study is a narrative review of original studies and case reports published in English and Polish between 1957 and 2021 that was conducted by searching electronic scientific resources: PubMed, Google Scholar, Web of Science, and Science Direct. The schema of the qualification process is represented by a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). In total, 196 articles were identified; after provisional assessment of the titles and abstracts by two reviewers, 46 were found to be relevant to the topic, including 1 review, 16 original papers, and 27 case reports regarding systemic disease resulting in premature tooth loss.
resultsIn this study, 16 systemic diseases were linked to premature primary tooth loss in children: Papillon-Lefèvre syndrome, mucocutaneous dyskeratosis, Coffin-Lowry syndrome, congenital adrenal hyperplasia, Langerhans cell histiocytosis, cherubism, hypophosphatasia, acatalasia, Chediak-Higashi syndrome, cyclic neutropenia, erythromelalgia, Down syndrome, Hajdu-Cheney syndrome, short bowel syndrome, leukocyte adhesion deficiency type 1 (LAD-1), and Wiedemann-Steiner syndrome (WSS).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.