Evidence map›Paper›PMID 35328809›Full record

ReviewInternational journal of molecular sciences2022

Extracellular Vesicles: Interplay with the Extracellular Matrix and Modulated Cell Responses.

Aleen Al Halawani, Suzanne M Mithieux, Giselle C Yeo, Elham Hosseini-Beheshti, Anthony S Weiss

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Expression of vesiculation-related genes is associated with a tumor-promoting microenvironment: a pan-cancer analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aleen Al HalawaniCharles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
Suzanne M MithieuxCharles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.
Giselle C YeoCharles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0001-6071-8899
Elham Hosseini-BeheshtiSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-1342-4844
Anthony S WeissCharles Perkins Centre, The University of Sydney, Camperdown, NSW 2006, Australia.ORCID 0000-0002-8106-4836

Funding

Australian Research Council ARCDust Diseases Board Competitive GrantNational Health and Medical Research Council APP1195827
6 · The paper itself

Abstract

The discovery that cells secrete extracellular vesicles (EVs), which carry a variety of regulatory proteins, nucleic acids, and lipids, has shed light on the sophisticated manner by which cells can communicate and accordingly function. The bioactivity of EVs is not only defined by their internal content, but also through their surface associated molecules, and the linked downstream signaling effects they elicit in target cells. The extracellular matrix (ECM) contains signaling and structural molecules that are central to tissue maintenance and repair. Recently, a subset of EVs residing within the extracellular matrix has been identified. Although some roles have been proposed for matrix-bound vesicles, their role as signaling molecules within the ECM is yet to be explored. Given the close association of EVs and the ECM, it is not surprising that EVs partly mediate repair and regeneration by modulating matrix deposition and degradation through their cellular targets. This review addresses unique EV features that allow them to interact with and navigate through the ECM, describes how their release and content is influenced by the ECM, and emphasizes the emerging role of stem-cell derived EVs in tissue repair and regeneration through their matrix-modulating properties.

Indexed as

Extracellular VesiclesNucleic AcidsBiological TransportExtracellular MatrixStem CellsNucleic Acidsexosomesextracellular matrixextracellular vesiclesmatrix-bound vesiclesmesenchymal stem cellsmicrovesiclestissue repairwound healing

Identifiers

PMID35328809
PMCPMC8954001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.