ReviewInternational journal of molecular sciences2022
Deep Eutectic Solvent as Green Solvent in Extraction of Biological Macromolecules: A Review.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 266 citations in OpenAlex.
- Molecular dynamics provide insights into the purification of tea membrane-bound polyphenol oxidase through three-phase partitioning utilizing an eco-friendly deep eutectic solvent.Food chemistry: X · 2026Article
- Extraction of Phenolic Compounds from the Pulp ofACS omega · 2026Article
- Disruption or partitioning? Deep eutectic solvent biphasic systems for integrated seaweed biorefineries.Bioresources and bioprocessing · 2026Article
- Overcoming Biomass Recalcitrance Heterogeneity Using a Surfactant-Based CTAB/LA/CuApplied biochemistry and biotechnology · 2026Article
- Optimized microwave pretreatment and ultrasound-assisted deep eutectic solvent extraction for efficient valorization of Citrus paradisi peel bioactives.Bioresources and bioprocessing · 2026Article
- An integrated approach: green extraction technique optimization, mechanistic study, and bioactivity profiling of four flavonoids fromRSC advances · 2026Article
- Computationally optimized molecularly imprinted electrochemical sensor based on biomass-derived biochar for paclobutrazol analysis in Radix Angelicae Sinensis.RSC advances · 2026Article
- Ultrasonic-assisted ternary deep eutectic solvent extraction of polysaccharides from fermented black beans (Dan-Dou-Chi): structural features, antioxidant, and hypoglycemic activities.Food chemistry: X · 2026Article
- Deep eutectic solvent-mediated extraction of collagen peptides from sturgeon skin: Molecular-weight control and mechanistic insights.Food chemistry: X · 2026Article
- Polyphenols in food and food wastes: Extraction, isolation, and health applications.Food chemistry. Molecular sciences · 2026Review
- Natural Colorants From Amazonian Plants: Bioactive Potential and Sustainable Extraction Techniques-A Review.Food science & nutrition · 2026Article
- Deep eutectic solvent extraction and AB-8 resin adsorption for rambutan shell polyphenol: Profiling and bioactivity assessments.Food chemistry: X · 2026Article
- Integrated sonication-assisted deep eutectic solvent for extraction of antibacterial compounds from cacao shells.RSC advances · 2026Article
- Tuning the Solvation and Solubility Properties of Molecularly Heterogeneous Nonionic Deep Eutectic Solvents via Interface Organization.Langmuir : the ACS journal of surfaces and colloids · 2026Article
- Green ultrasound-assisted extraction for efficient carotenoid profiling of calamansi (Citrofortunella microcarpa).Ultrasonics sonochemistry · 2026Article
- Deep Eutectic Solvents for Sustainable Extraction of Bioactive Compounds from Biomass: Mechanistic Insights and Scale-Up Challenges.Molecules (Basel, Switzerland) · 2026Review
- Targeted Separation ofFoods (Basel, Switzerland) · 2026Article
- Simultaneous ultrasound-microwave assisted deep eutectic solvent extraction of essential oil from calamansi (Citrus × microcarpa) peel: optimization, volatile profiling, and antioxidant activities.Ultrasonics sonochemistry · 2026Article
- Current Status and Future Perspectives of Betaine and Betaine-Based Natural Deep Eutectic Solvents: A Review.Foods (Basel, Switzerland) · 2025Review
- Process optimization and antioxidant activity of white peony root components extracted via ultrasound-assisted deep eutectic solvents.Ultrasonics sonochemistry · 2025Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Greater awareness of environmental sustainability has driven many industries to transition from using synthetic organic solvents to greener solvents in their manufacturing. Deep eutectic solvents (DESs) have emerged as a highly promising category of green solvents with well-demonstrated and wide-ranging applications, including their use as a solvent in extraction of small-molecule bioactive compounds for food and pharmaceutical applications. The use of DES as an extraction solvent of biological macromolecules, on the other hand, has not been as extensively studied. Thereby, the feasibility of employing DES for biomacromolecule extraction has not been well elucidated. To bridge this gap, this review provides an overview of DES with an emphasis on its unique physicochemical properties that make it an attractive green solvent (e.g., non-toxicity, biodegradability, ease of preparation, renewable, tailorable properties). Recent advances in DES extraction of three classes of biomacromolecules-i.e., proteins, carbohydrates, and lipids-were discussed and future research needs were identified. The importance of DES's properties-particularly its viscosity, polarity, molar ratio of DES components, and water addition-on the DES extraction's performance were discussed. Not unlike the findings from DES extraction of bioactive small molecules, DES extraction of biomacromolecules was concluded to be generally superior to extraction using synthetic organic solvents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.