ReviewInternational journal of molecular sciences2022
Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06980259 (Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Spatially Fractionated Radiotherapy Versus Conventional Radiotherapy in the Treatment of Soft Tissue Sarcoma:A Multicenter，Prospective, Phase II, Randomized Controlled Trial
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness and Safety of Lattice Radiotherapy in Treating Large Volume Tumors: A Systematic Review and Meta-analysis Based on Single-arm Clinical Studies.Balkan medical journal · 2025Pooled it
- A dosimetric study of photon energy and flattening filter mode combinations in Stereotactic Central Ablative Radiotherapy.Journal of applied clinical medical physics · 2026Article
- A single-field-each-peak optimization method for motion-robust proton LATTICE therapy.Medical physics · 2026Article
- A preclinical setup for spatially fractionated radiation therapy with electrons.Medical physics · 2026Article
- Spatially fractionated radiotherapy versus conventional radiotherapy in the treatment of soft tissue sarcoma: A multicenter, prospective, phase II, randomized controlled clinical trial protocol.Precision radiation oncology · 2026Article
- Study on the effects of estimated dose of radiation to immune cells and CBC parameters on the prognosis of patients with locally advanced non-small cell lung cancer undergoing radiotherapy.Frontiers in immunology · 2026Article
- Case Report: Spatially fractionated radiation therapy for local recurrence after prior radiotherapy in advanced right-sided small cell lung cancer with mediastinal lymph node metastases.Frontiers in oncology · 2026Article
- Development of a preclinical X-rays minibeam Monte Carlo treatment planning system.Scientific reports · 2025Article
- The Combination of Temporal and Spatial Dose Fractionation in Microbeam Radiation Therapy.Biomedicines · 2025Article
- Proton minibeam radiotherapy: a review.Frontiers in oncology · 2025Review
- SFRT combined with immunotherapy for a growing hepatocellular carcinoma after the failure of anti-angiogenesis and anti-PD1 treatment: a case report.Frontiers in oncology · 2025Article
- Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical review.Physical and engineering sciences in medicine · 2024Review
- The oxygen puzzle in FLASH radiotherapy: A comprehensive review and experimental outlook.Clinical and translational radiation oncology · 2024Review
- Rotationally Intensified Proton Lattice: A Novel Lattice Technique Using Spot-Scanning Proton Arc Therapy.Advances in radiation oncology · 2024Article
- Spatially fractionated radiotherapy (Lattice SFRT) in the palliative treatment of locally advanced bulky unresectable head and neck cancer.Clinical and translational radiation oncology · 2024Article
- Dosimetric characterization for GRID collimator-based spatially fractionated radiation therapy: Dosimetric parameter acquisition and machine interchangeability investigation.Journal of applied clinical medical physics · 2024Article
- Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Review
- Tuning spatially fractionated radiotherapy dose profiles using the moiré effect.Scientific reports · 2024Article
- Combining spatially fractionated radiation therapy (SFRT) and immunotherapy opens new rays of hope for enhancing therapeutic ratio.Clinical and translational radiation oncology · 2024Review
- Immune Priming with Spatially Fractionated Radiation Therapy.Current oncology reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The continuously evolving field of radiotherapy aims to devise and implement techniques that allow for greater tumour control and better sparing of critical organs. Investigations into the complexity of tumour radiobiology confirmed the high heterogeneity of tumours as being responsible for the often poor treatment outcome. Hypoxic subvolumes, a subpopulation of cancer stem cells, as well as the inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. Non-conventional irradiation techniques, such as spatially fractionated radiotherapy, have been developed to tackle some of these challenges and to offer a high therapeutic index when treating radioresistant tumours. The goal of this article was to highlight the current knowledge on the molecular and radiobiological mechanisms behind spatially fractionated radiotherapy and to present the up-to-date preclinical and clinical evidence towards the therapeutic potential of this technique involving both photon and proton beams.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.