Evidence map›Paper›PMID 35328748›Full record

ArticleInternational journal of molecular sciences2022

Intracerebral but Not Peripheral Infection of Live

Chairmandurai Aravindraja, Ravi Sakthivel, Xuefei Liu, Marshall Goodwin, Patnam Veena, Valentina Godovikova, J Christopher Fenno, Yona Levites, Todd E Golde, Lakshmyya Kesavalu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review
  7. Review
  8. Unique miRomics Expression Profiles inInternational journal of molecular sciences · 2023
    Article
  9. Review
  10. Oral SpirocheteInternational journal of molecular sciences · 2023
    Article
  11. Specific microRNA Signature Kinetics inInternational journal of molecular sciences · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Chairmandurai AravindrajaDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-7699-8300
Ravi SakthivelDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-5159-6030
Xuefei LiuDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Marshall GoodwinDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Patnam VeenaDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-4409-5040
Valentina GodovikovaDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.
J Christopher FennoDepartment of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.ORCID 0000-0002-7073-7855
Yona LevitesDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Todd E GoldeDepartment of Neuroscience, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Lakshmyya KesavaluDepartment of Periodontology, College of Dentistry, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-8828-8656
University of Florida · USUniversity of Michigan · US

Funding

Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
Periodontal bacteria and Alzheimer?s diseaseR21NS102926 · NINDS · UNIVERSITY OF FLORIDA · PI LAKSHMYYA, KESAVALU NAIDU · 2017 to 2018
$419k
Ed & Ethel Moore Alzheimer's disease- Florida Department of Health 8AZ15NIDCR NIH HHS DE025225NIDCR NIH HHS R01 DE025225NINDS NIH HHS R21 NS102926-02
6 · The paper itself

Abstract

The impact of oral microbial dysbiosis on Alzheimer's disease (AD) remains controversial. Building off recent studies reporting that various microbes might directly seed or promote amyloid β (Aβ) deposition, we evaluated the effects of periodontal bacteria (

Indexed as

Alzheimer DiseaseAmyloidosisAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalGliosisMiceMice, Inbred C57BLMice, TransgenicPlaque, AmyloidPorphyromonas gingivalisAmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAlzheimer’s diseaseamyloid β plaquesAPP-TgCRND8 mouse modelgliosisintracerebral infectionperiodontitis

Identifiers

PMID35328748
PMCPMC8954230
OpenAlexW4220999109

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.