Evidence map›Paper›PMID 35328632›Full record

ArticleInternational journal of molecular sciences2022

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na

Melissa J Ruggiero, Shipra Malhotra, Aron W Fenton, Liskin Swint-Kruse, John Karanicolas, Bruno Hagenbuch

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Amino acid substitutions at rheostat positions in the NaProtein science : a publication of the Protein Society · 2025
    Article
  2. Article
  3. Article
  4. Rheostatic contributions to protein stability can obscure a position's functional role.Protein science : a publication of the Protein Society · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Melissa J RuggieroDepartment of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Shipra MalhotraProgram in Molecular Therapeutics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Aron W FentonDepartment of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Liskin Swint-KruseDepartment of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
John KaranicolasProgram in Molecular Therapeutics, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.ORCID 0000-0003-0300-726X
Bruno HagenbuchDepartment of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.ORCID 0000-0002-2938-8630
University of Kansas Medical Center · USFox Chase Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Nuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1M
Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WEINMAN, STEVEN A · 2016 to 2020
$5.5M
Molecular Characterization of Hepatic Organic Anion Transporting PolypeptidesR01GM077336 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HAGENBUCH, BRUNO · 2007 to 2019
$3.7M
Towards exome analyses: Surprising outcomes from mutating nonconserved positionsR01GM118589 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI FENTON, ARON W, LAMB, AUDREY L · 2017 to 2020
$1.3M
NIH HHS P20GM103549NIH HHS P30CA006927NIH HHS P30GM118247NIH HHS R01GM077336NIH HHS R01GM118589W.M. Keck Fountation NA
6 · The paper itself

Abstract

In the Na

Indexed as

Organic Anion Transporters, Sodium-DependentSymportersAmino Acid SubstitutionHumansMembrane Transport ProteinsPeptidesPolymorphism, GeneticTaurocholic AcidMembrane Transport ProteinsOrganic Anion Transporters, Sodium-DependentPeptidesSymportersTaurocholic Acidprotein plasticityrheostattransmembrane protein

Identifiers

PMID35328632
PMCPMC8954283
OpenAlexW4221036182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.