Evidence map›Paper›PMID 35328577›Full record

ReviewInternational journal of molecular sciences2022

From Cancer Therapy to Winemaking: The Molecular Structure and Applications of β-Glucans and β-1, 3-Glucanases.

Catarina Caseiro, Joana Nunes Ribeiro Dias, Carlos Mendes Godinho de Andrade Fontes, Pedro Bule

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 91 citations in OpenAlex.

  1. Review
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  6. Article
  7. Antidiabetic Potential ofMolecules (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
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  14. Review
  15. Review
  16. Review
  17. Article
  18. Quantification of Mixed-Linkage β-Glucan (MLG) in Bacteria.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  19. Potential ofPlants (Basel, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Catarina CaseiroCIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.
Joana Nunes Ribeiro DiasCIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.ORCID 0000-0003-1905-1871
Carlos Mendes Godinho de Andrade FontesNZYTech Genes & Enzymes, 1649-038 Lisbon, Portugal.
Pedro BuleCIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, Portugal.ORCID 0000-0003-2531-9926
University of Lisbon · PTNzytech (Portugal) · PT

Funding

ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Agencia de Inovacao LISBOA-01-0247-FEDER-047033Fundação para a Ciência e Tecnologia SFRH/BD/147152/2019Fundação para a Ciência e Tecnologia UIDB/00276/2020NIGMS NIH HHS R01 GM129325
6 · The paper itself

Abstract

β-glucans are a diverse group of polysaccharides composed of β-1,3 or β-(1,3-1,4) linked glucose monomers. They are mainly synthesized by fungi, plants, seaweed and bacteria, where they carry out structural, protective and energy storage roles. Because of their unique physicochemical properties, they have important applications in several industrial, biomedical and biotechnological processes. β-glucans are also major bioactive molecules with marked immunomodulatory and metabolic properties. As such, they have been the focus of many studies attesting to their ability to, among other roles, fight cancer, reduce the risk of cardiovascular diseases and control diabetes. The physicochemical and functional profiles of β-glucans are deeply influenced by their molecular structure. This structure governs β-glucan interaction with multiple β-glucan binding proteins, triggering myriad biological responses. It is then imperative to understand the structural properties of β-glucans to fully reveal their biological roles and potential applications. The deconstruction of β-glucans is a result of β-glucanase activity. In addition to being invaluable tools for the study of β-glucans, these enzymes have applications in numerous biotechnological and industrial processes, both alone and in conjunction with their natural substrates. Here, we review potential applications for β-glucans and β-glucanases, and explore how their functionalities are dictated by their structure.

Indexed as

beta-GlucansNeoplasmsFungiMolecular StructurePlantsPolysaccharidesbeta-GlucansPolysaccharidescancerCR3Dectin-1molecular structurevaccinesβ-glucanasesβ-glucans

Identifiers

PMID35328577
PMCPMC8949617
OpenAlexW4221066293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.