Evidence map›Paper›PMID 35328573›Full record

ArticleInternational journal of molecular sciences2022

Bee Venom and Its Major Component Melittin Attenuated

Hyemin Gu, Hyun-Jin An, Mi-Gyeong Gwon, Seongjae Bae, Jaechan Leem, Sun-Jae Lee, Sang-Mi Han, Christos C Zouboulis, Kwan-Kyu Park

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Therapeutic Bioactivity Exerted by theMolecules (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Pharmacological properties and therapeutic potential of honey bee venom.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hyemin GuDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Hyun-Jin AnDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Mi-Gyeong GwonDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Seongjae BaeDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Jaechan LeemDepartment of Immunology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.ORCID 0000-0003-2329-4374
Sun-Jae LeeDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.ORCID 0000-0002-8552-6049
Sang-Mi HanDepartment of Agricultural Biology, National Academy of Agricultural Science, RDA, Wanju 54875, Korea.ORCID 0000-0002-6840-4509
Christos C ZouboulisDepartments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Faculty of Health Sciences Brandenburg, Auenweg 38, 06847 Dessau, Germany.ORCID 0000-0003-1646-2608
Kwan-Kyu ParkDepartment of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Daegu Catholic University · KRMedizinische Hochschule Brandenburg Theodor Fontane · DENational Academy of Agricultural Science · KR

Funding

This work was carried out with the support of "Cooperative Research Program for Agriculture Science and Technology Development (Project No. PJ015634)" Rural Development Administration, Republic of Korea. PJ015634
6 · The paper itself

Abstract

Acne vulgaris is the most common disease of the pilosebaceous unit. The pathogenesis of this disease is complex, involving increased sebum production and perifollicular inflammation. Understanding the factors that regulate sebum production is important in identifying novel therapeutic targets for the treatment of acne. Bee Venom (BV) and melittin have multiple effects including antibacterial, antiviral, and anti-inflammatory activities in various cell types. However, the anti-lipogenic mechanisms of BV and melittin have not been elucidated. We investigated the effects of BV and melittin in models of Insulin-like growth factor-1 (IGF-1) or

Indexed as

Acne VulgarisBee VenomsAnti-Inflammatory AgentsHumansInsulin-Like Growth Factor IMelittenPropionibacterium acnesProto-Oncogene Proteins c-aktSignal TransductionSirolimusSterol Regulatory Element Binding Protein 1TOR Serine-Threonine KinasesAnti-Inflammatory AgentsBee VenomsInsulin-Like Growth Factor IMelittenMTOR protein, humanProto-Oncogene Proteins c-aktSirolimusSterol Regulatory Element Binding Protein 1TOR Serine-Threonine Kinasesbee venomC. acnesIGF-1lipogenesismelittin

Identifiers

PMID35328573
PMCPMC8953527
OpenAlexW4220963725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.