Evidence map›Paper›PMID 35328483›Full record

ArticleInternational journal of molecular sciences2022

Gene-Delivery Ability of New Hydrogenated and Partially Fluorinated

Michele Massa, Mirko Rivara, Gaetano Donofrio, Luigi Cristofolini, Erica Peracchia, Carlotta Compari, Franco Bacciottini, Davide Orsi, Valentina Franceschi, Emilia Fisicaro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Development of Self-AssemblingMolecules (Basel, Switzerland) · 2023
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Michele MassaDepartment of Maternal Infantile and Urological Sciences, Sapienza University of Rome, 00165 Rome, Italy.
Mirko RivaraDepartment Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0001-6809-0020
Gaetano DonofrioDepartment of Veterinary Sciences, University of Parma, Via del Taglio 10, 43126 Parma, Italy.
Luigi CristofoliniDepartment of Mathematical, Physical and Computer Science, University of Parma, Parco Area delle Scienze 7/a, 43124 Parma, Italy.ORCID 0000-0003-2440-4934
Erica PeracchiaDepartment Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Carlotta CompariDepartment Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Franco BacciottiniDepartment Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Davide OrsiDepartment of Mathematical, Physical and Computer Science, University of Parma, Parco Area delle Scienze 7/a, 43124 Parma, Italy.ORCID 0000-0003-3223-8622
Valentina FranceschiDepartment of Veterinary Sciences, University of Parma, Via del Taglio 10, 43126 Parma, Italy.ORCID 0000-0003-3945-2285
Emilia FisicaroDepartment Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.ORCID 0000-0002-6083-482X
University of Parma · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pandemic emergency determined by the spreading worldwide of the SARS-CoV-2 virus has focused the scientific and economic efforts of the pharmaceutical industry and governments on the possibility to fight the virus by genetic immunization. The genetic material must be delivered inside the cells by means of vectors. Due to the risk of adverse or immunogenic reaction or replication connected with the more efficient viral vectors, non-viral vectors are in many cases considered as a preferred strategy for gene delivery into eukaryotic cells. This paper is devoted to the evaluation of the gene delivery ability of new synthesized

Indexed as

Gene Transfer TechniquesA549 CellsCell SurvivalDNAGenetic TherapyHalogenationHumansHydrogenationMethaneMicroscopy, Atomic ForceMolecular StructurePlasmidsPyridinium CompoundsReproducibility of ResultsSurface-Active AgentsTransfectionDNAMethanePyridinium CompoundsSurface-Active Agentsatomic force microscopy on DNADNA-surfactant interactiongene deliverygene therapyheterocyclic gemini cationic surfactantsnonviral vectorspartially fluorinated gemini surfactants

Identifiers

PMID35328483
PMCPMC8949414
OpenAlexW4221015026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.