ArticleInternational journal of molecular sciences2022
Alteration of Oral and Perioral Soft Tissue in Mice following Incisor Tooth Extraction.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Nano zero-valent iron-mediated sodium alginate/polyacrylic acid composite hydrogel: evaluation of hemostatic effects on post-extraction bleeding in anticoagulated mice.BMC oral health · 2026Article
- Dual attachment of the buccinator muscle at the pterygoid hamulus: implications for pterygoid implant surgery.International journal of implant dentistry · 2025Article
- Anatomical study of pterygoid implants: artery and nerve passage through bone dehiscence of the greater palatine canal.International journal of implant dentistry · 2024Article
- Effects of Myostatin on Nuclear Morphology at the Myotendinous Junction.International journal of molecular sciences · 2023Article
- Development and Regeneration of Muscle, Tendon, and Myotendinous Junctions in Striated Skeletal Muscle.International journal of molecular sciences · 2022Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
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Abstract
Oral and perioral soft tissues cooperate with other oral and pharyngeal organs to facilitate mastication and swallowing. It is essential for these tissues to maintain their morphology for efficient function. Recently, it was reported that the morphology of oral and perioral soft tissue can be altered by aging or orthodontic treatment. However, it remains unclear whether tooth loss can alter these tissues' morphology. This study examined whether tooth loss could alter lip morphology. First, an analysis of human anatomy suggested that tooth loss altered lip morphology. Next, a murine model of tooth loss was established by extracting an incisor; micro-computed tomography revealed that a new bone replaced the extraction socket. Body weight was significantly lower in the tooth loss (UH) group than in the non-extraction control (NH) group. The upper lip showed a greater degree of morphological variation in the UH group. Proteomic analysis and immunohistochemical staining of the upper lip illustrated that S100A8/9 expression was higher in the UH group, suggesting that tooth loss induced lip inflammation. Finally, soft-diet feeding improved lip deformity associated with tooth loss, but not inflammation. Therefore, soft-diet feeding is essential for preventing lip morphological changes after tooth loss.
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