ReviewInternational journal of molecular sciences2022
Hypothyroidism and Diabetes-Related Dementia: Focused on Neuronal Dysfunction, Insulin Resistance, and Dyslipidemia.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Letter to the Editor in response to "Association between thyroid dysfunction and cognitive impairment in type 2 Diabetes Mellitus: A cross-sectional study".Journal of diabetes investigation · 2026Article
- Review
- Development of a machine learning-based prediction model for hypothyroidism-associated delirium in elderly hypothyroid patients in the intensive care unit.BMC geriatrics · 2026Article
- Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross-sectional study.Journal of diabetes investigation · 2026Article
- Beyond Hormone Levels: Thyroid Hormone Signaling from Neurogenesis to Alzheimer's Disease.Cells · 2026Review
- Analysis of Anxiety and Depression Status and Risk Factors in Postmenopausal Women With Diabetes Mellitus Complicated by Hypothyroidism.Actas espanolas de psiquiatria · 2026Article
- Prevalence and pattern of cognitive dysfunction in young adults and middle-aged patients with type-2 diabetes.Journal of family medicine and primary care · 2025Article
- Associations between indicators of lipid and glucose metabolism and hypothyroidism.Lipids in health and disease · 2025Article
- Thyroid-Stimulating Hormone Regulates the Glucose Metabolism in Hepatocytes via Toll-Like Receptor 4/Tollip Pathway.International journal of endocrinology · 2025Article
- Thyroid functions and insulin resistance in pregnant Sudanese women.BMC endocrine disorders · 2024Article
- Machine Learning Approach with Harmonized Multinational Datasets for Enhanced Prediction of Hypothyroidism in Patients with Type 2 Diabetes.Diagnostics (Basel, Switzerland) · 2024Article
- Association between pain interference and motoric cognitive risk syndrome in older adults: a population-based cohort study.BMC geriatrics · 2024Article
- Thyroid-stimulating hormone may participate in insulin resistance by activating toll-like receptor 4 in liver tissues of subclinical hypothyroid rats.Molecular biology reports · 2023Article
- Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice.Frontiers in pharmacology · 2023Article
- Cardiovascular and Neuronal Consequences of Thyroid Hormones Alterations in the Ischemic Stroke.Metabolites · 2022Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The incidence of dementia is steadily increasing worldwide. The risk factors for dementia are diverse, and include genetic background, environmental factors, sex differences, and vascular abnormalities. Among the subtypes of dementia, diabetes-related dementia is emerging as a complex type of dementia related to metabolic imbalance, due to the increase in the number of patients with metabolic syndrome and dementia worldwide. Thyroid hormones are considered metabolic regulatory hormones and affect various diseases, such as liver failure, obesity, and dementia. Thyroid dysregulation affects various cellular mechanisms and is linked to multiple disease pathologies. In particular, hypothyroidism is considered a critical cause for various neurological problems-such as metabolic disease, depressive symptoms, and dementia-in the central nervous system. Recent studies have demonstrated the relationship between hypothyroidism and brain insulin resistance and dyslipidemia, leading to diabetes-related dementia. Therefore, we reviewed the relationship between hypothyroidism and diabetes-related dementia, with a focus on major features of diabetes-related dementia such as insulin resistance, neuronal dysfunction, and dyslipidemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.