Evidence map›Paper›PMID 35328378›Full record

ArticleInternational journal of molecular sciences2022

Mechanical-Stress-Related Epigenetic Regulation of

Harish K Datta, Marianne K Kringen, Stephen P Tuck, Georgia Salpingidou, Ole K Olstad, Kaare M Gautvik, Simon J Cockell, Vigdis T Gautvik, Michael Prediger, Jun Jie Wu and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Harish K DattaMusculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-4729-9340
Marianne K KringenCenter for Psychopharmacology, Diakonhjemmet Hospital, 0319 Oslo, Norway.
Stephen P TuckMusculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0001-5060-4214
Georgia SalpingidouDepartment of Engineering, Faculty of Science, Durham University, Durham DH1 3 LE, UK.
Ole K OlstadDepartment of Medical Biochemistry, Oslo University Hospital, 0424 Oslo, Norway.
Kaare M GautvikUnger-Vetlesen Institute, Lovisenberg Diaconal Hospital, 0440 Oslo, Norway.
Simon J CockellSchool of Biomedical, Nutritional and Sport Sciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-6831-9806
Vigdis T GautvikUnger-Vetlesen Institute, Lovisenberg Diaconal Hospital, 0440 Oslo, Norway.
Michael PredigerBlood Sciences, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle upon Tyne NE2 4HH, UK.
Jun Jie WuDepartment of Engineering, Faculty of Science, Durham University, Durham DH1 3 LE, UK.
Mark A BirchMusculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Sjur ReppeDepartment of Medical Biochemistry, Oslo University Hospital, 0424 Oslo, Norway.ORCID 0000-0002-4330-5379
Newcastle University · GBDurham University · GBLovisenberg Diakonale Sykehus · NOOslo University Hospital · NODiakonhjemmet Hospital · NORoyal Victoria Infirmary · GBSouth Tees Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MR/R015635/1This project was supported by the National Osteoporosis Society (# BH121971), EPSRC (EP/K036939/1), Knowledge Transfer Account from Lovisenberg Diaconal Hospital Oslo, South-Eastern Norway Regional Health Authority (Oslo University Hospital) (Project 2975 # BH121971, EP/K036939/1,Project 29750104,FP6 - 502491
6 · The paper itself

Abstract

Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the neurological transcriptional factor zinc finger of the cerebellum 1 (

Indexed as

Osteoporosis, PostmenopausalAnimalsBone DensityEpigenesis, GeneticFemaleHumansIliumLumbar VertebraeRatsRNA, MessengerStress, MechanicalTranscription FactorsRNA, MessengerTranscription FactorsZIC1 protein, humanboneepigeneticmechanical stressosteoporosisZIC1 transcription factor

Identifiers

PMID35328378
PMCPMC8955993
OpenAlexW4220759192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.