Evidence map›Paper›PMID 35328227›Full record

ArticleDiagnostics (Basel, Switzerland)2022

Gene Expression Analysis of Biphasic Pleural Mesothelioma: New Potential Diagnostic and Prognostic Markers.

Rossella Bruno, Anello Marcello Poma, Greta Alì, Claudia Distefano, Agnese Proietti, Antonio Chella, Marco Lucchi, Franca Melfi, Renato Franco, Gabriella Fontanini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rossella BrunoUnit of Pathological Anatomy, University Hospital of Pisa, 56100 Pisa, Italy.
Anello Marcello PomaDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56100 Pisa, Italy.ORCID 0000-0002-0212-8249
Greta AlìUnit of Pathological Anatomy, University Hospital of Pisa, 56100 Pisa, Italy.
Claudia DistefanoUnit of Pathological Anatomy, University Hospital of Pisa, 56100 Pisa, Italy.
Agnese ProiettiUnit of Pathological Anatomy, University Hospital of Pisa, 56100 Pisa, Italy.
Antonio ChellaUnit of Pneumology, University Hospital of Pisa, 56100 Pisa, Italy.ORCID 0000-0002-4325-759X
Marco LucchiDivision of Thoracic Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56100 Pisa, Italy.
Franca MelfiMinimally Invasive and Robotic Thoracic Surgery, Robotic Multispecialty Center of Surgery, University Hospital of Pisa, 56100 Pisa, Italy.ORCID 0000-0002-1773-8269
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania "L Vanvitelli", 80138 Naples, Italy.ORCID 0000-0002-8340-3184
Gabriella FontaniniDepartment of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, 56100 Pisa, Italy.
Azienda Ospedaliera Universitaria Pisana · ITUniversity of Pisa · ITUniversity of Campania "Luigi Vanvitelli" · IT

Funding

The Kazan McClain Partners' Foundation micro research grant IMIG 2018 attendees
6 · The paper itself

Abstract

Biphasic is the second most common histotype of pleural mesothelioma (PM). It shares epithelioid and sarcomatoid features and is challenging to diagnose. The aim of this study was to identify biphasic PM markers to improve subtyping and prognosis definition. The expression levels of 117 cancer genes, evaluated using the nanoString system, were compared between the three major histotypes (epithelioid, sarcomatoid, and biphasic), and expression differences within biphasic PM were evaluated in relation to the percentage of epithelioid components. Biphasic PM overexpressed

Indexed as

biomarkersbiphasic pleural mesotheliomadiagnosisgene expressionnanoString systemprognosis

Identifiers

PMID35328227
PMCPMC8947498
OpenAlexW4221065454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.