Evidence map›Paper›PMID 35328112›Full record

ReviewDiagnostics (Basel, Switzerland)2022

Non-Gestational Ovarian Choriocarcinoma: A Rare Ovarian Cancer Subtype.

Sean Cronin, Nishat Ahmed, Amaranta D Craig, Stephanie King, Min Huang, Christina S Chu, Gina M Mantia-Smaldone

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sean CroninDepartment of Obstetrics and Gynecology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
Nishat AhmedDepartment of Obstetrics and Gynecology, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
Amaranta D CraigDepartment of Surgical Oncology, Division of Gynecology Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0002-0233-9089
Stephanie KingDepartment of Surgical Oncology, Division of Gynecology Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Min HuangDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Christina S ChuDepartment of Surgical Oncology, Division of Gynecology Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Gina M Mantia-SmaldoneDepartment of Surgical Oncology, Division of Gynecology Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.ORCID 0000-0001-8223-3059
Fox Chase Cancer Center · USEinstein Medical Center Philadelphia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-Gestational Ovarian Choriocarcinoma (NGOC) is an extremely rare ovarian tumor, with an incidence of less than 0.6% of malignant ovarian germ cell tumors. Its close pathologic resemblance to Gestational Ovarian Choriocarcinoma (GOC), however, requires special attention as the treatments differ greatly. NGOC typically affects patients in late adolescence or early reproductive years. As a result, NGOCs are often misdiagnosed as ectopic pregnancies due to their common presentation of bleeding, abdominal pain, adnexal mass, and positive serum beta-HCG. On pathologic examination, the tumor is indistinguishable from GOC, and only after review of tissue for paternal genetic components can the diagnosis of NGOC be made. Imaging studies often show highly vascular lesions with further investigation with computer topography (CT) sometimes showing metastatic lesions in the lungs, pelvis, vagina, and liver. These lesions are often hemorrhagic and can lead to catastrophic bleeding. Treatment is vastly different from GOC; NGOC requires treatment with both surgical resection and chemotherapy, with Bleomycin, Etoposide, and Cisplatin (BEP) being the most used regimen. With correct diagnosis and treatment, patients can often receive fertility sparing treatment with long term survival.

Indexed as

germ cell tumorsnon-gestational ovarian choriocarcinomaovarian tumorrare ovarian tumors

Identifiers

PMID35328112
PMCPMC8947355
OpenAlexW4213259446

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.