Evidence map›Paper›PMID 35328107›Full record

ArticleGenes2022

Note on DNA Analysis and Redesigning Using Markov Chain.

Maciej Zakarczemny, Małgorzata Zajęcka

Abstract read
In one paragraph

Article in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maciej ZakarczemnyDepartment of Applied Mathematics, Faculty of Computer Science and Telecommunications, Cracow University of Technology (CUT), 24 Warszawska Street, 31-155 Cracow, Poland.ORCID 0000-0002-7202-1244
Małgorzata ZajęckaDepartment of Applied Mathematics, Faculty of Computer Science and Telecommunications, Cracow University of Technology (CUT), 24 Warszawska Street, 31-155 Cracow, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paper contains a discussion on mathematical modifying and redesigning DNA with the use of Markov chains. We give a simple mathematical technique for overwriting missing parts of DNA. With a certain probability (without even knowing the function of the missing codon) we can find a synonymous codon, so that there is no frequency change in amino acid sequences of proteins. We use Markov Chain to analyze the dependencies in DNA sequence of the human gene Alpha 1,3-Galactosyltransfe rase 2. We include a theoretical introduction which facilitates the understanding of the paper for non-mathematicians, especially for biologists not familiar with the theory of Markov chains.

Indexed as

DNAAmino Acid SequenceCodonHumansMarkov ChainsProbabilityCodonDNADNAhuman geneMarkov chain

Identifiers

PMID35328107
PMCPMC8953815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.