Evidence map›Paper›PMID 35328082›Full record

ReviewGenes2022

An Expanding Toolkit for Heterochromatin Repair Studies.

Chetan C Rawal, Nadejda L Butova, Anik Mitra, Irene Chiolo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chetan C RawalMolecular and Computational Biology Department, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-9286-927X
Nadejda L ButovaMolecular and Computational Biology Department, University of Southern California, Los Angeles, CA 90089, USA.
Anik MitraMolecular and Computational Biology Department, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-0589-0044
Irene ChioloMolecular and Computational Biology Department, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-3080-550X

Funding

Roles of nuclear architecture and phase separation in heterochromatin repair dynamicsR01GM117376 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIOLO, IRENE E · 2015 to 2023
$3.3M
NIGMS NIH HHS R01 GM117376
6 · The paper itself

Abstract

Pericentromeric heterochromatin is mostly composed of repetitive DNA sequences prone to aberrant recombination. Cells have developed highly specialized mechanisms to enable 'safe' homologous recombination (HR) repair while preventing aberrant recombination in this domain. Understanding heterochromatin repair responses is essential to understanding the critical mechanisms responsible for genome integrity and tumor suppression. Here, we review the tools, approaches, and methods currently available to investigate double-strand break (DSB) repair in pericentromeric regions, and also suggest how technologies recently developed for euchromatin repair studies can be adapted to characterize responses in heterochromatin. With this ever-growing toolkit, we are witnessing exciting progress in our understanding of how the 'dark matter' of the genome is repaired, greatly improving our understanding of genome stability mechanisms.

Indexed as

DNA Breaks, Double-StrandedHeterochromatinDNA RepairEuchromatinRecombinational DNA RepairEuchromatinHeterochromatindouble-strand break repairgenome stabilityhomologous recombinationnuclear dynamicspericentromeric heterochromatinrepeated sequences

Identifiers

PMID35328082
PMCPMC8955653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.