Evidence map›Paper›PMID 35327955›Full record

SynthesisGenes2022

Is

Mika Saito, Michał Ginszt, Ekaterina A Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michałowska-Sawczyn, Hiroki Homma, Paweł Cięszczyk, Takanobu Okamoto, Andrey K Larin and 5 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mika SaitoGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan.
Michał GinsztDepartment of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-059 Lublin, Poland.ORCID 0000-0002-0800-6103
Ekaterina A SemenovaDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0003-1248-2855
Myosotis MassiddaDepartment of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.ORCID 0000-0001-5726-4435
Kinga Huminska-LisowskaFaculty of Physical Education, Gdańsk University of Physical Education and Sport, 80-854 Gdańsk, Poland.ORCID 0000-0003-0034-0809
Monika Michałowska-SawczynFaculty of Physical Education, Gdańsk University of Physical Education and Sport, 80-854 Gdańsk, Poland.
Hiroki HommaGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan.
Paweł CięszczykFaculty of Physical Education, Gdańsk University of Physical Education and Sport, 80-854 Gdańsk, Poland.ORCID 0000-0002-7735-7580
Takanobu OkamotoGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan.
Andrey K LarinDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, 119435 Moscow, Russia.
Edward V GenerozovDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, 119435 Moscow, Russia.
Piotr MajcherDepartment of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-059 Lublin, Poland.
Koichi NakazatoGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan.ORCID 0000-0002-2479-5771
Ildus I AhmetovDepartment of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, 119435 Moscow, Russia.ORCID 0000-0002-6335-4020
Naoki KikuchiGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan.ORCID 0000-0001-5901-7307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = −0.216, p < 0.001; AC: r = −0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes.

Indexed as

Polymorphism, GeneticSportsCollagen Type I, alpha 1 ChainFemaleGenotypeHumansMaleRussiaCOL1A1 protein, humanCollagen Type I, alpha 1 ChainagingCOL1A1flexibilitygenotypeheterozygositypolymorphismsit-and-reachsports climbing

Identifiers

PMID35327955
PMCPMC8954011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.