Evidence map›Paper›PMID 35327650›Full record

ArticleBiomolecules2022

Multicenter

Michael Rullmann, Matthias Brendel, Matthias L Schroeter, Dorothee Saur, Johannes Levin, Robert G Perneczky, Solveig Tiepolt, Marianne Patt, Andre Mueller, Victor L Villemagne and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Associations of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
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  5. Article
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  7. Developing a novel reference region for [European journal of nuclear medicine and molecular imaging · 2025
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  8. Rates of clinical progression according to biological Alzheimer's disease stages.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  9. Review
  10. Multi-parametric [European journal of nuclear medicine and molecular imaging · 2025
    Article
  11. Article
  12. Article
  13. Assessment of [European journal of nuclear medicine and molecular imaging · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Michael RullmannDepartment of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-2683-9432
Matthias BrendelDepartment of Nuclear Medicine, University Hospital of Munich, LMU Munich, 80336 Munich, Germany.
Matthias L SchroeterClinic for Cognitive Neurology, University of Leipzig, 04103 Leipzig, Germany.
Dorothee SaurDepartment of Neurology, University of Leipzig, 04103 Leipzig, Germany.
Johannes LevinDepartment of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.ORCID 0000-0001-5092-4306
Robert G PerneczkyMunich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
Solveig TiepoltDepartment of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.
Marianne PattDepartment of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.
Andre MuellerLife Molecular Imaging GmbH, 13353 Berlin, Germany.ORCID 0000-0001-7271-9303
Victor L VillemagneDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Joseph ClassenDepartment of Neurology, University of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-7182-6967
Andrew W StephensLife Molecular Imaging GmbH, 13353 Berlin, Germany.
Osama SabriDepartment of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.
Henryk BarthelDepartment of Nuclear Medicine, University of Leipzig, 04103 Leipzig, Germany.
On Behalf Of The German Imaging Initiative For Tauopathies Gii T

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tau aggregates accumulate in the Alzheimer's disease (AD) brain according to the established Braak staging scheme and spread from transentorhinal over limbic regions to the neocortex. To impact the management of AD patients, an in vivo tool for tau Braak staging is needed. First-generation tau tracers have limited performance in detecting early stages of tau. Therefore, we tested the corresponding capability of the next-generation tau tracer,

Indexed as

Alzheimer DiseaseTauopathiesBrainFluorine RadioisotopesHumansNeurofibrillary TanglesPositron-Emission TomographyPyridinestau Proteins((18)F)PI-2620Fluorine RadioisotopesPyridinestau ProteinsAlzheimer’s diseaseBraak stagingPETPI-2620Tau

Identifiers

PMID35327650
PMCPMC8946049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.