Evidence map›Paper›PMID 35327579›Full record

ReviewBiomolecules2022

Amino Acid Signaling for TOR in Eukaryotes: Sensors, Transducers, and a Sustainable Agricultural fuTORe.

Nanticha Lutt, Jacob O Brunkard

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Rapid COThe Plant journal : for cell and molecular biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Genetic suppressor ofFrontiers in plant science · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Nanticha LuttLaboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA.
Jacob O BrunkardLaboratory of Genetics, University of Wisconsin, Madison, WI 53706, USA.ORCID 0000-0001-6407-9393
Agricultural Research Service · US

Funding

An aminoacyl tRNA synthetase is a nitrogen sensor that activates TOR in plantsDP5OD023072 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI BRUNKARD, JACOB O · 2016 to 2020
$1.6M
NIH HHS DP5 OD023072
6 · The paper itself

Abstract

Eukaryotic cells monitor and regulate metabolism through the atypical protein kinase target of rapamycin (TOR) regulatory hub. TOR is activated by amino acids in animals and fungi through molecular signaling pathways that have been extensively defined in the past ten years. Very recently, several studies revealed that TOR is also acutely responsive to amino acid metabolism in plants, but the mechanisms of amino acid sensing are not yet established. In this review, we summarize these discoveries, emphasizing the diversity of amino acid sensors in human cells and highlighting pathways that are indirectly sensitive to amino acids, i.e., how TOR monitors changes in amino acid availability without a

Indexed as

Amino AcidsSirolimusAnimalsEukaryotaPlantsSignal TransductionTransducersAmino AcidsSirolimusamino acid signalingArabidopsis thalianaCastor1GATORGCN2metabolismmTORRagulatorSestrin2target of rapamycin

Identifiers

PMID35327579
PMCPMC8945916
OpenAlexW4214846319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.