Evidence map›Paper›PMID 35327414›Full record

ArticleBiomedicines2022

Association of Neuropathic Pain Symptoms with Sensitization Related Symptomatology in Women with Fibromyalgia.

Edurne Úbeda-D'Ocasar, Juan Antonio Valera-Calero, Gracia María Gallego-Sendarrubias, César Fernández-de-Las-Peñas, José Luis Arias-Buría, Matilde Morales-Cabezas, Lars Arendt-Nielsen, Margarita Cigarán-Méndez

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05701696 (Investigation of the Relationship Between Neuropathic Complaints and Central Sensitization in Patients With Fibromyalgia), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05701696 unknown statusnot on this mapstarted 2023, after this paper: background citation

Investigation of the Relationship Between Neuropathic Complaints and Central Sensitization in Patients With Fibromyalgia

TypeobservationalSponsorMarmara UniversityRan2023 to 2023Enrolled111ConditionsCentral Sensitisation, Fibromyalgia, Neuropathic PainArmsCentral sensitization inventory, Widespread pain index, Symptom severity scale, Fibromyalgia impact questionnaire, Hospital Anxiety and Depression Scale
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Electrophysiological Evidence for Impaired Central Pain Modulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Edurne Úbeda-D'OcasarDepartment of Physiotherapy, Faculty of Health, Universidad Camilo José Cela, 28692 Villanueva de la Cañada, Spain.
Juan Antonio Valera-CaleroDepartment of Physiotherapy, Faculty of Health, Universidad Camilo José Cela, 28692 Villanueva de la Cañada, Spain.ORCID 0000-0002-3379-8392
Gracia María Gallego-SendarrubiasDepartment of Physiotherapy, Faculty of Health, Universidad Camilo José Cela, 28692 Villanueva de la Cañada, Spain.ORCID 0000-0002-3471-3717
César Fernández-de-Las-PeñasDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.ORCID 0000-0003-3772-9690
José Luis Arias-BuríaDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.ORCID 0000-0001-8548-4427
Matilde Morales-CabezasDepartment of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
Lars Arendt-NielsenCenter for Neuroplasticity and Pain (CNAP), Sanse-Motorisk Interaktion (SMI), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, 9220 Aalborg, Denmark.ORCID 0000-0003-0892-1579
Margarita Cigarán-MéndezDepartment of Psychology, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain.
Universidad Rey Juan Carlos · ESCamilo José Cela University · ESAalborg University Hospital · DK

Funding

Camilo José Cela University MORQUACERMU
6 · The paper itself

Abstract

We aimed to analyze potential correlations between S-LANSS and PainDETECT with proxies for pain sensitization, e.g., the Central Sensitization Inventory (CSI) and pressure pain hyperalgesia (construct validity), pain-related or psychological variables (concurrent validity) in women with fibromyalgia (FMS). One-hundred-and-twenty-six females with FMS completed demographic, pain-related variables, psychological, and sensitization outcomes as well as the S-LANSS and the PainDETECT questionnaires. S-LANSS was positively associated with BMI (r = 0.206), pain intensity (r = 0.206 to 0.298) and CSI score (r = 0.336) and negatively associated with all PPTs (r = -0.180 to -0.336). PainDETECT was negatively associated with age (r = -0.272) and all PPTs (r = -0.226 to -0.378) and positively correlated with pain intensity (r = 0.258 to 0.439), CSI (r = 0.538), anxiety (r = 0.246) and depression (r = 0.258). 51.4% of the S-LANSS was explained by PainDETECT (45.3%), posterior iliac PPT (0.2%) and mastoid PPT (5.9%), whereas the 56.4% of PainDETECT was explained by S-LANSS (43.4%), CSI (10.4%), and pain intensity (2.6%). This study found good convergent association between S-LANSS and PainDETECT in women with FMS. Additionally, S-LANSS was associated with PPTs whereas PainDETECT was associated with pain intensity and CSI, suggesting that both questionnaires assess different spectrums of the neuropathic and pain sensitization components of a condition and hence provide synergistic information.

Indexed as

chronic painfibromyalgianeuropathic painpressure thresholdsensitization

Identifiers

PMID35327414
PMCPMC8945759
OpenAlexW4220788167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.