Evidence map›Paper›PMID 35327389›Full record

ReviewBiomedicines2022

Clinical Applications of Cancer-Associated Cells Present in the Blood of Cancer Patients.

Cha-Mei Tang, Daniel L Adams

Abstract readReview
In one paragraph

Review in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cha-Mei TangCreatv MicroTech, Inc., 9900 Belward Campus Drive, Suite 330, Rockville, MD 20850, USA.
Daniel L AdamsCreatv MicroTech, Inc., 9 Deer Park Drive, Suite M5, Middlesex County, NJ 08852, USA.

Funding

I-Corps for SBIR Phase I: Giant Macrophage-like Cells as a blood-based Biomarker for Lung Cancer RecurrenceR43CA206840 · NCI · CREATV MICROTECH, INC. · PI LIN, STEVEN HSESHENG, TANG, CHA-MEI · 2017 to 2019
$305k
Defense Advanced Research Projects Agency (DARPA) W911NF-14-C-0098NCI NIH HHS R43CA206840
6 · The paper itself

Abstract

The ability to obtain tumor material from cells in the blood of cancer patients provides a significant benefit over the use of tumor tissue as a diagnostic to make treatment decisions. However, the traditionally defined circulating tumor cell (CTC) has been shown to be useful only in some cases. A recently identified type of circulating stromal cell, which appears to be more frequent than CTCs, was found engulfing tumor material at the tumor site and then entering the blood stream. These cells were defined as cancer-associated macrophage-like cells (CAMLs). Together, CTCs and CAMLs may be able to provide information for cancer detection and diagnosis, without the use of tissue. CTCs and CAMLs have many clinical applications, three of which are summarized in this review: for prognosis, as companion diagnostics, and for residual disease monitoring.

Indexed as

cancer-associated macrophage-like cells CAMLscirculating tumor cellscompanion diagnosticsCTCsimmunotherapyPD-L1residual disease

Identifiers

PMID35327389
PMCPMC8945841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.