Evidence map›Paper›PMID 35327377›Full record

ArticleBiomedicines2022

Placental Insulin Receptor Transiently Regulates Glucose Homeostasis in the Adult Mouse Offspring of Multiparous Dams.

Grace Chung, Ramkumar Mohan, Megan Beetch, Seokwon Jo, Emilyn Uy Alejandro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Grace ChungDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Ramkumar MohanDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Megan BeetchDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Seokwon JoDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Emilyn Uy AlejandroDepartment of Integrative Biology and Physiology, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-7941-8439
University of Minnesota Medical Center · US

Funding

NIH HHS R01DK115720, R21HD100840
6 · The paper itself

Abstract

In pregnancies complicated by maternal obesity and gestational diabetes mellitus, there is strong evidence to suggest that the insulin signaling pathway in the placenta may be impaired. This may have potential effects on the programming of the metabolic health in the offspring; however, a direct link between the placental insulin signaling pathway and the offspring health remains unknown. Here, we aimed to understand whether specific placental loss of the insulin receptor (InsR) has a lasting effect on the offspring health in mice. Obesity and glucose homeostasis were assessed in the adult mouse offspring on a normal chow diet (NCD) followed by a high-fat diet (HFD) challenge. Compared to their littermate controls, InsR KO

Indexed as

fetal programminggestational diabetesmultiparityobesityplacental insulin receptortype 2 diabetes

Identifiers

PMID35327377
PMCPMC8945682
OpenAlexW4214643495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.